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Isorhamnetin 3-O-galactoside

Name: Isorhamnetin 3-O-galactoside
Brand: TargetMol
SKU: TN1793
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN1793Cas No. 6743-92-6

Alias Cacticin

Isorhamnetin 3-O-galactoside is a flavonoid glycoside isolated from Oenanthe javanica that exhibits potent antithrombotic and profibrinolytic activities by inhibiting thrombin and factor Xa functions, reducing the maximal rate of thrombin-catalyzed fibrin polymerization, suppressing TNF-α-induced PAI-1 secretion, lowering the PAI-1/t-PA ratio, and inhibiting FXa production and FVa/FXa-mediated thrombin generation, while also exerting hepatoprotective effects against carbon tetrachloride-induced liver injury in mice, enabling its use in research on thrombotic vascular disorders and hepatic disease.

Isorhamnetin 3-O-galactoside

🥰Excellent

Purity: 99.98%

Catalog No. TN1793Alias CacticinCas No. 6743-92-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$265	-	In Stock
10 mg	$430	-	In Stock
25 mg	$730	-	In Stock
50 mg	$1,095	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.98%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Isorhamnetin 3-O-galactoside is a flavonoid glycoside isolated from Oenanthe javanica that exhibits potent antithrombotic and profibrinolytic activities by inhibiting thrombin and factor Xa functions, reducing the maximal rate of thrombin-catalyzed fibrin polymerization, suppressing TNF-α-induced PAI-1 secretion, lowering the PAI-1/t-PA ratio, and inhibiting FXa production and FVa/FXa-mediated thrombin generation, while also exerting hepatoprotective effects against carbon tetrachloride-induced liver injury in mice, enabling its use in research on thrombotic vascular disorders and hepatic disease.
In vitro	Isorhamnetin 3-O-galactoside (0.5-50 μM, 18 hours) dose-dependently inhibits TNF-α-induced PAI-1 secretion in HUVECs [2]. Isorhamnetin 3-O-galactoside (1-5 μM, 6 hours) effectively suppresses LPS-induced HMGB1 release in HUVECs [3].
In vivo	For male ICR mice, intraperitoneal administration of Isorhamnetin 3-O-galactoside (50-200 mg/kg) 30 minutes before and 2 hours after CCl₄ injection effectively alleviated CCl₄-induced liver injury [1]. A single intravenous dose of 2.4 mg/kg Isorhamnetin 3-O-galactoside significantly prolonged tail bleeding time in experimental animals [2]. For CLP-induced septic male C57BL/6 mice, a single intravenous injection of 4.8 mg/mouse Isorhamnetin 3-O-galactoside significantly suppressed the release of high HMGB1 in vivo [3].
Synonyms	Cacticin

Chemical Properties

Molecular Weight	478.4
Formula	C₂₂H₂₂O₁₂
Cas No.	6743-92-6
Smiles	O(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2)C3=CC(OC)=C(O)C=C3)[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O
Relative Density.	1.759g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (167.22 mM), Sonication is recommeded.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0903 mL	10.4515 mL	20.9030 mL	104.5151 mL
5 mM	0.4181 mL	2.0903 mL	4.1806 mL	20.9030 mL
10 mM	0.2090 mL	1.0452 mL	2.0903 mL	10.4515 mL
20 mM	0.1045 mL	0.5226 mL	1.0452 mL	5.2258 mL
50 mM	0.0418 mL	0.2090 mL	0.4181 mL	2.0903 mL
100 mM	0.0209 mL	0.1045 mL	0.2090 mL	1.0452 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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