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Isorhamnetin 3-O-galactoside

Name: Isorhamnetin 3-O-galactoside
Brand: TargetMol
SKU: TN1793
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1793Cas No. 6743-92-6

Alias Cacticin

Isorhamnetin 3-O-galactoside is a flavonoid glycoside isolated from Oenanthe javanica that exhibits potent antithrombotic and profibrinolytic activities by inhibiting thrombin and factor Xa functions, reducing the maximal rate of thrombin-catalyzed fibrin polymerization, suppressing TNF-α-induced PAI-1 secretion, lowering the PAI-1/t-PA ratio, and inhibiting FXa production and FVa/FXa-mediated thrombin generation, while also exerting hepatoprotective effects against carbon tetrachloride-induced liver injury in mice, enabling its use in research on thrombotic vascular disorders and hepatic disease.

Isorhamnetin 3-O-galactoside

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Purity: 99.98%

Catalog No. TN1793Alias CacticinCas No. 6743-92-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$263	-	In Stock
10 mg	$428	-	In Stock
25 mg	$698	-	In Stock
50 mg	$968	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.98%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Isorhamnetin 3-O-galactoside is a flavonoid glycoside isolated from Oenanthe javanica that exhibits potent antithrombotic and profibrinolytic activities by inhibiting thrombin and factor Xa functions, reducing the maximal rate of thrombin-catalyzed fibrin polymerization, suppressing TNF-α-induced PAI-1 secretion, lowering the PAI-1/t-PA ratio, and inhibiting FXa production and FVa/FXa-mediated thrombin generation, while also exerting hepatoprotective effects against carbon tetrachloride-induced liver injury in mice, enabling its use in research on thrombotic vascular disorders and hepatic disease.
In vitro	Isorhamnetin 3-O-galactoside (0.5-50 μM, 18 hours) dose-dependently inhibits TNF-α-induced PAI-1 secretion in HUVECs [2]. Isorhamnetin 3-O-galactoside (1-5 μM, 6 hours) effectively suppresses LPS-induced HMGB1 release in HUVECs [3].
In vivo	For male ICR mice, intraperitoneal administration of Isorhamnetin 3-O-galactoside (50-200 mg/kg) 30 minutes before and 2 hours after CCl₄ injection effectively alleviated CCl₄-induced liver injury [1]. A single intravenous dose of 2.4 mg/kg Isorhamnetin 3-O-galactoside significantly prolonged tail bleeding time in experimental animals [2]. For CLP-induced septic male C57BL/6 mice, a single intravenous injection of 4.8 mg/mouse Isorhamnetin 3-O-galactoside significantly suppressed the release of high HMGB1 in vivo [3].
Synonyms	Cacticin

Chemical Properties

Molecular Weight	478.40
Formula	C₂₂H₂₂O₁₂
Cas No.	6743-92-6
Smiles	O(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2)C3=CC(OC)=C(O)C=C3)[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O
Relative Density.	1.759g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (167.22 mM), Sonication is recommeded.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0903 mL	10.4515 mL	20.9030 mL	104.5151 mL
5 mM	0.4181 mL	2.0903 mL	4.1806 mL	20.9030 mL
10 mM	0.2090 mL	1.0452 mL	2.0903 mL	10.4515 mL
20 mM	0.1045 mL	0.5226 mL	1.0452 mL	5.2258 mL
50 mM	0.0418 mL	0.2090 mL	0.4181 mL	2.0903 mL
100 mM	0.0209 mL	0.1045 mL	0.2090 mL	1.0452 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc