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Tezacaftor

Name: Tezacaftor
Brand: TargetMol
SKU: T2263
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2263Cas No. 1152311-62-0

Alias VX661

Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.

Tezacaftor

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Purity: 99.94%

Catalog No. T2263Alias VX661Cas No. 1152311-62-0

Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$75	In Stock
10 mg	$125	In Stock
25 mg	$223	In Stock
50 mg	$360	In Stock
100 mg	$531	In Stock
1 mL x 10 mM (in DMSO)	$90	In Stock

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
Targets&IC50	DEGS:3 µM
In vivo	The F508del mutation channel can avoid degradation and be transported to the cell membrane under the action of VX-661.
Synonyms	VX661

Chemical Properties

Molecular Weight	520.5
Formula	C₂₆H₂₇F₃N₂O₆
Cas No.	1152311-62-0
Smiles	CC(C)(CO)c1cc2cc(NC(=O)C3(CC3)c3ccc4OC(F)(F)Oc4c3)c(F)cc2n1C[C@@H](O)CO
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 245 mg/mL (470.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9212 mL	9.6061 mL	19.2123 mL	96.0615 mL
5 mM	0.3842 mL	1.9212 mL	3.8425 mL	19.2123 mL
10 mM	0.1921 mL	0.9606 mL	1.9212 mL	9.6061 mL
20 mM	0.0961 mL	0.4803 mL	0.9606 mL	4.8031 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9212 mL
100 mM	0.0192 mL	0.0961 mL	0.1921 mL	0.9606 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc