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Anti-PSMA Antibody (6F983)

😃Good
Catalog No. TMAY-02805
Alias PSMA, PSM, NAALAdase, NAALAD1, mGCP, GCPII, GCP2, FOLH, folate hydrolase (prostate-specific membrane antigen) 1, FGCP

Anti-PSMA Antibody (6F983) is a Mouse antibody targeting PSMA. Anti-PSMA Antibody (6F983) can be used in ICC/IF.

Anti-PSMA Antibody (6F983)

Anti-PSMA Antibody (6F983)

😃Good
Catalog No. TMAY-02805Alias PSMA, PSM, NAALAdase, NAALAD1, mGCP, GCPII, GCP2, FOLH, folate hydrolase (prostate-specific membrane antigen) 1, FGCP
Anti-PSMA Antibody (6F983) is a Mouse antibody targeting PSMA. Anti-PSMA Antibody (6F983) can be used in ICC/IF.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-PSMA Antibody (6F983) is a Mouse antibody targeting PSMA. Anti-PSMA Antibody (6F983) can be used in ICC/IF.
AliasPSMA, PSM, NAALAdase, NAALAD1, mGCP, GCPII, GCP2, FOLH, folate hydrolase (prostate-specific membrane antigen) 1, FGCP
Ig Type
Monoclonal Mouse IgG1
Clone
6F983
Reactivity
Human
Verified Activity
Immunofluorescence staining of S1h-3C-FOLH1 in LNCaP cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human S1h-3C-FOLH1 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm and Cell membrane.
Application
ICC/IF
Recommended Dose
ICC-IF: 1:20-1:100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PSMA / FOLH1 (rh PSMA / FOLH1; NP_004467.1Lys44-Ala750). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundGlutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human PSMA / FOLH1 Protein
Antigen Species
Human
Biology Area
Cancer Drug Targets, Neurotransmitter Associated Enzymes
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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