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Anti-PSMA Antibody (6F983)
😃Good
Catalog No. TMAY-02805
Alias PSMA, PSM, NAALAdase, NAALAD1, mGCP, GCPII, GCP2, FOLH, folate hydrolase (prostate-specific membrane antigen) 1, FGCP
Anti-PSMA Antibody (6F983) is a Mouse antibody targeting PSMA. Anti-PSMA Antibody (6F983) can be used in ICC/IF.
Anti-PSMA Antibody (6F983)
Anti-PSMA Antibody (6F983)
😃Good
Catalog No. TMAY-02805Alias PSMA, PSM, NAALAdase, NAALAD1, mGCP, GCPII, GCP2, FOLH, folate hydrolase (prostate-specific membrane antigen) 1, FGCP
Anti-PSMA Antibody (6F983) is a Mouse antibody targeting PSMA. Anti-PSMA Antibody (6F983) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ICC/IF Reactivity: Human |
| Alias | PSMA, PSM, NAALAdase, NAALAD1, mGCP, GCPII, GCP2, FOLH, folate hydrolase (prostate-specific membrane antigen) 1, FGCP |
| Ig Type | Mouse IgG1 |
| Clone | 6F983 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of S1h-3C-FOLH1 in LNCaP cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human S1h-3C-FOLH1 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm and Cell membrane. |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PSMA / FOLH1 (rh PSMA / FOLH1; NP_004467.1Lys44-Ala750). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human PSMA / FOLH1 Protein |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Neurotransmitter Associated Enzymes |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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