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MK-6892

Name: MK-6892
Brand: TargetMol
SKU: TQ0108
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0108Cas No. 917910-45-3

MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).

MK-6892

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Purity: 99.67%

Catalog No. TQ0108Cas No. 917910-45-3

MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).

Pack Size	Price	Availability
1 mg	$88	In Stock
5 mg	$198	In Stock
10 mg	$297	In Stock
25 mg	$497	In Stock
50 mg	$689	In Stock
100 mg	$987	In Stock
200 mg	$1,330	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock

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Batch Information

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Purity:99.67%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).
Targets&IC50	GPR109A:16 nM (EC50), GPR109A:4 nM (Ki)
In vitro	MK-6892 effectively induces the internalization of GPR109A in U2OS β-arrestin2-RrGFP cells and demonstrates a potent EC50 of 74 nM in calcium mobilization assays [2].
In vivo	MK-6892 is administered orally to WT and nicotinic acid (NA) receptor null mice on a C57Bl/6 genetic background. Following a 100 mg/kg dose, blood levels of MK-6892 reach 229 μM in WT mice and 148 μM in NA receptor null mice after 15 minutes, significantly exceeding the in vitro EC50 (240 nM). MK-6892 effectively suppresses plasma FFA in WT mice, but not in NA receptor null mice, indicating NA receptor-dependent FFA reduction [1].

Chemical Properties

Molecular Weight	386.4
Formula	C₁₉H₂₂N₄O₅
Cas No.	917910-45-3
Smiles	CC(C)(Cc1nc(no1)-c1ccc(O)cn1)C(=O)NC1=C(CCCC1)C(O)=O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (116.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5880 mL	12.9400 mL	25.8799 mL	129.3996 mL
5 mM	0.5176 mL	2.5880 mL	5.1760 mL	25.8799 mL
10 mM	0.2588 mL	1.2940 mL	2.5880 mL	12.9400 mL
20 mM	0.1294 mL	0.6470 mL	1.2940 mL	6.4700 mL
50 mM	0.0518 mL	0.2588 mL	0.5176 mL	2.5880 mL
100 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2940 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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