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Nitazoxanide

Name: Nitazoxanide
Brand: TargetMol
SKU: T1546
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1546Cas No. 55981-09-4

Alias NSC 697855

Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction.

Nitazoxanide

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Purity: 99.93%

Catalog No. T1546Alias NSC 697855Cas No. 55981-09-4

Pack Size	Price	Availability
10 mg	$38	In Stock
25 mg	$79	In Stock
50 mg	$127	In Stock
100 mg	$198	In Stock
500 mg	$455	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.93%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction.
Targets&IC50	Influenza virus ranges (canine):0.17-0.21 μM
In vitro	In a model of abiotic piglet diarrhea, oral administration of Nitazoxanide (250 mg/kg/day) was effective in reducing the survival of parasites within the host organism.
In vivo	Nitazoxanide effectively inhibits the growth of a broad spectrum of protozoans and helminths, such as Blastocystis hominis, Entamoeba histolytica, and Trichomonas vaginalis, without exhibiting cytotoxicity. It demonstrates inhibitory concentrations against E. histolytica (IC50=0.017 mg/mL, IC90=0.776 mg/mL), G. intestinalis (IC50=0.004 mg/mL, IC90=0.067 mg/mL), and T. vaginalis (IC50= 0.034 mg/mL, IC90=2.046 mg/mL).
Synonyms	NSC 697855

Chemical Properties

Molecular Weight	307.28
Formula	C₁₂H₉N₃O₅S
Cas No.	55981-09-4
Smiles	C(NC=1SC(N(=O)=O)=CN1)(=O)C2=C(OC(C)=O)C=CC=C2
Relative Density.	1.532 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (162.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (8.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2544 mL	16.2718 mL	32.5436 mL	162.7180 mL
5 mM	0.6509 mL	3.2544 mL	6.5087 mL	32.5436 mL
10 mM	0.3254 mL	1.6272 mL	3.2544 mL	16.2718 mL
20 mM	0.1627 mL	0.8136 mL	1.6272 mL	8.1359 mL
50 mM	0.0651 mL	0.3254 mL	0.6509 mL	3.2544 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6272 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc