Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chst15-IN-1 is a powerful, reversible, covalent inhibitor of the Chst15 enzyme. It effectively suppresses the sulfation levels of chondroitin sulfate-E (CS-E) and other closely related sulfotransferases responsible for glycosaminoglycans (GAGs) synthesis. Acting as a selective sulfotransferase inhibitor, Chst15-IN-1 can attenuate the inhibitory actions of chondroitin sulfate proteoglycans (CSPGs), making it a promising candidate for enhancing neuronal repair.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 53.00 |
Description | Chst15-IN-1 is a powerful, reversible, covalent inhibitor of the Chst15 enzyme. It effectively suppresses the sulfation levels of chondroitin sulfate-E (CS-E) and other closely related sulfotransferases responsible for glycosaminoglycans (GAGs) synthesis. Acting as a selective sulfotransferase inhibitor, Chst15-IN-1 can attenuate the inhibitory actions of chondroitin sulfate proteoglycans (CSPGs), making it a promising candidate for enhancing neuronal repair. |
In vitro | Chst15-IN-1, at concentrations of 25 μM for 24 hours in Neu7 astrocytes, demonstrates selectivity for sulfotransferases compared to a wide range of cysteine-reactive proteins. Furthermore, Chst15-IN-1 exhibits a significant dose-dependent reduction in cell-surface CS-E expression in Neu7 astrocytes at both 10 and 25 μM concentrations[1]. |
In vivo | Chst15-IN-1 (3.0 mg/kg; i.v.) demonstrates a moderate clearance rate of 21 mL/min/kg and a moderate volume of distribution at 0.97 L/kg, alongside a short terminal half-life of 1.6 hours in rats during pharmacokinetic analysis[1]. This summarizes its efficacy and disposition within the tested animal model. |
Synonyms | Chst15-IN-1 |
Molecular Weight | 442.09 |
Formula | C17H11BrCl2N2O3 |
CAS No. | 2158198-77-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Chst15-IN-1 2158198-77-5 Chst15IN1 Chst15 IN 1 Chst-15-IN-1 inhibitor inhibit