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Chst15-IN-1

Name: Chst15-IN-1
Brand: TargetMol
SKU: T39631
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39631Cas No. 2158198-77-5

Alias Chst15-IN-1

Chst15-IN-1 is a selective, reversible, covalent inhibitor of the Chst15 enzyme that suppresses sulfation of chondroitin sulfate-E (CS-E) and related sulfotransferases, attenuating the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs) and making it a promising candidate for promoting neuronal repair.

Chst15-IN-1

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Catalog No. T39631Alias Chst15-IN-1Cas No. 2158198-77-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	-	In Stock
5 mg	$77	-	In Stock
10 mg	$118	-	In Stock
25 mg	$198	-	In Stock
50 mg	$293	-	In Stock
100 mg	$433	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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COA HNMR

Product Introduction

Bioactivity

Description	Chst15-IN-1 is a selective, reversible, covalent inhibitor of the Chst15 enzyme that suppresses sulfation of chondroitin sulfate-E (CS-E) and related sulfotransferases, attenuating the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs) and making it a promising candidate for promoting neuronal repair.
In vitro	Chst15-IN-1, when acting on Neu7 astrocytes at a concentration of 25 μM for 24 hours, exhibits selectivity towards sulfotransferase, which is significantly higher than its selectivity towards various proteins containing active cysteine residues. At concentrations of 10 μM and 25 μM, Chst15-IN-1 significantly reduces the expression level of chondroitin sulfate-E (CS-E) on the cell surface of Neu7 astrocytes, with this reduction effect demonstrating a dose-dependent manner [1].
In vivo	Chst15-IN-1, when administered intravenously (i.v.) at a dose of 3.0 mg/kg, exhibits the following pharmacokinetic characteristics: moderate clearance with a value of 21 mL/(min・kg); moderate volume of distribution with a value of 0.97 L/kg; and a relatively short terminal half-life with a value of 1.6 hours [1].
Synonyms	Chst15-IN-1

Chemical Properties

Molecular Weight	442.09
Formula	C₁₇H₁₁BrCl₂N₂O₃
Cas No.	2158198-77-5
Smiles	N(C(/C(=C/C1=CC(OC)=C(O)C(Br)=C1)/C#N)=O)C2=C(Cl)C=C(Cl)C=C2
Relative Density.	1.677 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (90.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2620 mL	11.3099 mL	22.6198 mL	113.0991 mL
5 mM	0.4524 mL	2.2620 mL	4.5240 mL	22.6198 mL
10 mM	0.2262 mL	1.1310 mL	2.2620 mL	11.3099 mL
20 mM	0.1131 mL	0.5655 mL	1.1310 mL	5.6550 mL
50 mM	0.0452 mL	0.2262 mL	0.4524 mL	2.2620 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc