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Glycolithocholic acid

Name: Glycolithocholic acid
Brand: TargetMol
SKU: T31964
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31964Cas No. 474-74-8

Alias Lithocholylglycine, Lithocholic acid glycine conjugate

Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.

Glycolithocholic acid

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Purity: 99.83%

Catalog No. T31964Alias Lithocholylglycine, Lithocholic acid glycine conjugateCas No. 474-74-8

Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$672	-	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Glycolithocholic acid AI Summary

Glycolithocholic acid exhibits a range of biological activities across different systems. It acts as an agonist at the human TGR5 receptor expressed in CHO cells, with an EC50 value of 540.0 nM and an efficacy of 92.0% relative to lithocholic acid. It also inhibits the uptake of Taurocholate in Xenopus laevis oocytes by 24.0%, and at a concentration of 20 µM, it shows 9.0% inhibition of Taurocholate uptake in MRP4-expressing V79 cells in the presence of Lithoglycocholate. Additionally, Glycolithocholic acid inhibits the uptake of Estradiol-17beta-D-glucuronide by Glycolithocholate in MRP8-expressing LLC-PK1 cells, with 16.0% inhibition observed at 10 µM. The compound also exhibits antagonist activity at EphA2 in human PC3 cells, inhibiting ephrin-A1-Fc-stimulated EphA2 phosphorylation with an IC50 of 138,000.0 nM and ephrin-A1-Fc binding to EphA2-Fc receptor with an IC50 of 48,977.88 nM. Furthermore, it acts as an antagonist against VDR-LBD, inhibiting coactivator peptide recruitment, and shows cytotoxicity against HEK293T cells by reducing cell viability. Lastly, Glycolithocholic acid inhibits human alpha-2,6-ST6GAL1 and rat alpha-2,3-O-ST3GALI, affecting sialylated-product formation in glycosylation processes as assessed by reverse-phase HPLC analysis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.
Synonyms	Lithocholylglycine, Lithocholic acid glycine conjugate

Chemical Properties

Molecular Weight	433.62
Formula	C₂₆H₄₃NO₄
Cas No.	474-74-8
Smiles	[H][C@@]12CC[C@H]([C@H](C)CCC(=O)NCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C
Relative Density.	1.112g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247 mg/mL (569.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3062 mL	11.5308 mL	23.0617 mL	115.3083 mL
5 mM	0.4612 mL	2.3062 mL	4.6123 mL	23.0617 mL
10 mM	0.2306 mL	1.1531 mL	2.3062 mL	11.5308 mL
20 mM	0.1153 mL	0.5765 mL	1.1531 mL	5.7654 mL
50 mM	0.0461 mL	0.2306 mL	0.4612 mL	2.3062 mL
100 mM	0.0231 mL	0.1153 mL	0.2306 mL	1.1531 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc