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PMX 205 Trifluoroacetate (514814-49-4 free base)

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Catalog No. T12506
Alias PMX 205 Trifluoroacetate

PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.

PMX 205 Trifluoroacetate (514814-49-4 free base)
Other Forms of PMX 205 Trifluoroacetate (514814-49-4 free base):

PMX 205 Trifluoroacetate (514814-49-4 free base)

😃Good
Catalog No. T12506Alias PMX 205 Trifluoroacetate
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$113InquiryInquiry
5 mg$296InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.
In vitro
PMX205, which is an antagonist, gave more effects towards the cell as compared with the treatment of EP54.
In vivo
oral delivery of a cyclic hexapeptide C5a receptor antagonist (PMX205) for 2-3 mo resulted in substantial reduction of pathological markers such as fibrillar amyloid deposits (49-62%) and activated glia (42-68%) in two mouse models of AD. The reduction in pathology was correlated with improvements in a passive avoidance behavioral task in Tg2576 mice. In 3xTg mice, PMX205 also significantly reduced hyperphosphorylated tau (69%). These data provide the first evidence that inhibition of a proinflammatory receptor-mediated function of the complement cascade (i.e., C5aR) can interfere with neuroinflammation and neurodegeneration in AD rodent models, suggesting a novel therapeutic target for reducing pathology and improving cognitive function in human AD patients[3].
SynonymsPMX 205 Trifluoroacetate
Chemical Properties
Molecular Weight953.06
FormulaC47H63F3N10O8
SmilesOC(C(F)(F)F)=O.O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@](NC(CCC2=CC=CC=C2)=O)([H])CCCNC([C@H](CCCNC(N)=N)NC3=O)=O)=O)=O)CC4CCCCC4)N[C@@]3([H])CC5=CNC6=CC=CC=C56
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (104.93 mM), Sonication is recommended.
H2O: 0.67 mg/mL (0.7 mM), Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

PMX-205 TrifluoroacetatePMX205 TrifluoroacetatePMX 205 Trifluoroacetate (514814494 free base)PMX 205 Trifluoroacetate (514814 49 4 free base)514814-49-4 free base514814-49-4
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