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SCH442416

Name: SCH442416
Brand: TargetMol
SKU: T23336
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23336Cas No. 316173-57-6

Alias SCH 442416

SCH442416 (SCH 442416) is an selective antagonist of adenosine A2A receptor. SCH442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).

SCH442416

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Purity: 99.58%

Catalog No. T23336Alias SCH 442416Cas No. 316173-57-6

SCH442416 (SCH 442416) is an selective antagonist of adenosine A2A receptor. SCH442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$85	In Stock	In Stock
10 mg	$142	In Stock	In Stock
25 mg	$296	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$637	In Stock	In Stock
200 mg	$896	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.58%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SCH442416 (SCH 442416) is an selective antagonist of adenosine A2A receptor. SCH442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).
Targets&IC50	A2A receptor (rat):0.5 nM (IC50), A2A receptor (human):0.048 nM (IC50)
In vitro	The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions[1].
Synonyms	SCH 442416

Chemical Properties

Molecular Weight	389.41
Formula	C₂₀H₁₉N₇O₂
Cas No.	316173-57-6
Smiles	COc1ccc(CCCn2ncc3c2nc(N)n2nc(nc32)-c2ccco2)cc1
Relative Density.	1.49 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (154.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5680 mL	12.8399 mL	25.6799 mL	128.3994 mL
5 mM	0.5136 mL	2.5680 mL	5.1360 mL	25.6799 mL
10 mM	0.2568 mL	1.2840 mL	2.5680 mL	12.8399 mL
20 mM	0.1284 mL	0.6420 mL	1.2840 mL	6.4200 mL
50 mM	0.0514 mL	0.2568 mL	0.5136 mL	2.5680 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc