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Lansoprazole sulfide

Name: Lansoprazole sulfide
Brand: TargetMol
SKU: T21128
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21128Cas No. 103577-40-8

Alias AG-1777, AG1777

Lansoprazole sulfide (AG-177) is an active metabolite of Lansoprazole with similar activity.Lansoprazole is a proton pump inhibitor and antitubercular agent with an IC50= 0.59 µM against Mycobacterium tuberculosis.

Lansoprazole sulfide

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Purity: 99.78%

Catalog No. T21128Alias AG-1777, AG1777Cas No. 103577-40-8

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1 g	$310	In Stock

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Purity:99.78%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description	Lansoprazole sulfide (AG-177) is an active metabolite of Lansoprazole with similar activity.Lansoprazole is a proton pump inhibitor and antitubercular agent with an IC50= 0.59 µM against Mycobacterium tuberculosis.
Targets&IC50	M. tuberculosis:0.59 μM
In vitro	Lansoprazole sulfide exhibits anti-tuberculosis activity, showing an IC₅₀ of 0.59 µM against Mycobacterium tuberculosis[1].
Alias	AG-1777, AG1777

Chemical Properties

Molecular Weight	353.36
Formula	C₁₆H₁₄F₃N₃OS
Cas No.	103577-40-8
Smiles	FC(F)(F)COC=1C=CN=C(C1C)CSC2=NC=3C=CC=CC3N2
Relative Density.	1.41

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

Solubility Information

DMSO: 2 mg/mL (5.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8300 mL	14.1499 mL	28.2998 mL	141.4988 mL
5 mM	0.5660 mL	2.8300 mL	5.6600 mL	28.2998 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc