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Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody

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Catalog No. TMAB-10836

Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IFNAR1 (Ser535+Ser539). Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.

Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody

Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody

😃Good
Catalog No. TMAB-10836
Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IFNAR1 (Ser535+Ser539). Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IFNAR1 (Ser535+Ser539). Anti-Phospho-IFNAR1 (Ser535+Ser539) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,GuineaPig)
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2ug/tets
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane.
Tissue SpecificityIFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundIFNAR1 is a member of the cytokine receptor superfamily which also includes receptors for interleukins, IFN gamma, ciliary neurotrophic factor, somatotrophin, erythropoietin, nerve growth factor, tumor necrosis factor, leukemia inhibitory factor, and oncostatin M. Some members of the family have an alpha chain with either low or high ligand binding affinity and at least one beta chain involved in signal transduction with either relatively low or no ligand binding affinity. Type I interferons, alpha and beta, induce a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. The alpha and beta interferons compete to bind to a common cell surface receptor, while IFN gamma binds to a distinct receptor. IFNAR1 is very responsive to type I interferons and bind to IFN beta and IFN alpha subtypes. It is also functionally involved in signal transduction because of its association with the cytoplasmic tyrosine kinase JAK1. The type I interferons, alpha and beta, are produced by leukocytes (alpha subunits), fibroblasts (beta subtypes), lymphocytes (omega subtypes), and ruminant embryos (tau subtypes). Interferon receptors are generally found on most human cell types whatever their origin, even on cells poorly responsive to interferon. IFNAR1 is expressed on the cell surface in a variety of human cell lines.
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human IFNAR1 around the phosphorylation site of Ser535+Ser539
Antigen Species
Human
Gene Name
IFNAR1
Gene ID
Protein Name
Interferon alpha/beta receptor 1
Uniprot ID
Function
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Chemical Properties
Molecular WeightTheoretical: 61 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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