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Anti-NME1/NM23A Polyclonal Antibody 2
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Catalog No. TMAB-09531
Anti-NME1/NM23A Polyclonal Antibody 2 is a Rabbit antibody targeting NME1/NM23A. Anti-NME1/NM23A Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,ELISA,WB.
Anti-NME1/NM23A Polyclonal Antibody 2
Anti-NME1/NM23A Polyclonal Antibody 2
😃Good
Catalog No. TMAB-09531
Anti-NME1/NM23A Polyclonal Antibody 2 is a Rabbit antibody targeting NME1/NM23A. Anti-NME1/NM23A Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,ELISA,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NME1/NM23A Polyclonal Antibody 2 is a Rabbit antibody targeting NME1/NM23A. Anti-NME1/NM23A Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,ELISA,WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000; WB: 1:500 - 1:1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. |
| Tissue Specificity | Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. |
| Immunogen | KLH conjugated synthetic peptide: human Nm23 |
| Antigen Species | Human |
| Gene Name | NME1 |
| Gene ID | |
| Protein Name | Nucleoside diphosphate kinase A |
| Uniprot ID | |
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. |
| Molecular Weight | Theoretical: 17 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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