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6-Thioguanine

Name: 6-Thioguanine
Brand: TargetMol
SKU: T3089
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3089Cas No. 154-42-7

Alias Thioguanine, 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine

6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

6-Thioguanine

🥰Excellent

Purity: 98.75%

Catalog No. T3089Alias Thioguanine, 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurineCas No. 154-42-7

6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

Pack Size	Price	Availability
50 mg	$40	In Stock
100 mg	$48	In Stock
500 mg	$72	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:98.75%

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Product Introduction

Bioactivity

Description	6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Targets&IC50	Plpro:25 μM, USP2:40 μM
In vitro	6-Thioguanine selectively kills BRCA2-deficient tumors in xenograft models as effectively as PARP inhibitors. It eradicates cells and tumors that have developed resistance to PARP inhibitors or cisplatin through genetic reversal via the BRCA2 gene. Additionally, 6-Thioguanine is effective in eliminating PARP inhibitor-resistant tumors with BRCA1 deficiencies.
In vivo	6-Thioguanine is integrated into DNA, differing from typical DNA bases as it serves as a potent UVA chromophore with a peak absorbance at 342 nm. Its incorporation alters topoisomerase II-induced DNA cleavage both in the presence and absence of etoposide. Additionally, 6-Thioguanine induces similar apoptotic responses in mismatch repair-proficient and -deficient HCT116 and HeLa cells.
Synonyms	Thioguanine, 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine

Chemical Properties

Molecular Weight	167.19
Formula	C₅H₅N₅S
Cas No.	154-42-7
Smiles	NC1=NC2=C(N=CN2)C(S)=N1
Relative Density.	2.08 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (299.06 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9812 mL	29.9061 mL	59.8122 mL	299.0609 mL
5 mM	1.1962 mL	5.9812 mL	11.9624 mL	59.8122 mL
10 mM	0.5981 mL	2.9906 mL	5.9812 mL	29.9061 mL
20 mM	0.2991 mL	1.4953 mL	2.9906 mL	14.9530 mL
50 mM	0.1196 mL	0.5981 mL	1.1962 mL	5.9812 mL
100 mM	0.0598 mL	0.2991 mL	0.5981 mL	2.9906 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc