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Oxytocin

Name: Oxytocin
Brand: TargetMol
SKU: T5026
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5026Cas No. 50-56-6

Alias α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone

Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering.

Oxytocin

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Purity: 99.87%

Catalog No. T5026Alias α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormoneCas No. 50-56-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	-	In Stock
10 mg	$57	-	In Stock
25 mg	$94	-	In Stock
50 mg	$138	-	In Stock
100 mg	$209	-	In Stock
200 mg	$325	-	In Stock
500 mg	$593	-	In Stock
1 g	$945	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Oxytocin AI Summary

Oxytocin exhibits a variety of bioactivities, including high binding affinity to the oxytocin receptor (OTR) and vasopressin receptors in different tissues. It acts as an oxytocin receptor antagonist in rat uterine strips both in vitro and in vivo, showing uterotonic activity with varying potency in the presence and absence of Mg2+, and displaying milk ejection activity. The compound demonstrates vasopressor activity and antidiuretic activity in rat models, affecting urinary volume, and electrolyte excretion. It has an EC50 of 0.4 nM for the oxytocin receptor in human cells and shows a preference for the vasopressin V1a receptor with an EC50 of 0.08 nM compared to higher values for the V2 receptor. Oxytocin also shows agonist activity at human vasopressin and oxytocin receptors, affecting intracellular calcium levels in assays. It demonstrates stability in gastric fluid but lower stability in intestinal fluid, indicating potential challenges in oral bioavailability. Additionally, it exhibits good pharmacokinetic properties such as high binding affinity and short half-life in different species, with no significant adverse effects on liver cells. The compound's multifunctional profile, including potent agonist and antagonist activities, makes it a candidate for further exploration in modulating hormonal pathways related to oxytocin and vasopressin receptors..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering.
Targets&IC50	CHO cells:24.5 nM (EC50), CHO-K1 cells:2.3 nM (EC50), COS-1 cells:15 nM (EC50)
In vitro	METHODS: KGN, MA-10 and C18-4 cells were treated with Tris(2,4-di-tert-butylphenyl)phosphate (0.1-100 µM) for 48 h. Cell counts were measured by Hoechst 33342 stained. RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate was not cytotoxic to any of the 3 cell lines. [1]
In vivo	METHODS: To assay acute anti-inflammatory activity in vivo, Tris(2,4-di-tert-butylphenyl)phosphate (50-70 mg/kg, 0.1% sodium carboxymethyl cellulose in 1M phosphate buffer pH 7.2) was administered to a carrageenan-induced rat foot-plantar edema model. RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate at the doses of 50 mg/kg and 70 mg/kg showed significant anti-inflammatory activity in the carrageenan-induced foot-plantar edema model. Tris(2,4-di-tert-butylphenyl)phosphate significantly reduced the volume of raw paw edema. [2]
Synonyms	α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone

Chemical Properties

Molecular Weight	1007.19
Formula	C₄₃H₆₆N₁₂O₁₂S₂
Cas No.	50-56-6
Smiles	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
Relative Density.	1.27 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (99.29 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9929 mL	4.9643 mL	9.9286 mL	49.6431 mL
5 mM	0.1986 mL	0.9929 mL	1.9857 mL	9.9286 mL
10 mM	0.0993 mL	0.4964 mL	0.9929 mL	4.9643 mL
20 mM	0.0496 mL	0.2482 mL	0.4964 mL	2.4822 mL
50 mM	0.0199 mL	0.0993 mL	0.1986 mL	0.9929 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc