Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

LG100754

Name: LG100754
Brand: TargetMol
SKU: T15748
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T15748Cas No. 180713-37-5

Alias UVI 2112

LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.

LG100754

Copy Product Info

😃Good

Catalog No. T15748Alias UVI 2112Cas No. 180713-37-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$993	6-8 weeks	6-8 weeks
50 mg	$1,290	6-8 weeks	6-8 weeks
100 mg	$1,970	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White to Yellow

Resource Download

COA

Product Introduction

Bioactivity

Description	LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.
In vitro	LG100754 functions as an activator of endogenous RXR heterodimers, specifically facilitating the activity of RXR: PPARγ heterodimers. It plays a crucial role in regulating insulin-dependent signaling pathways. Additionally, LG100754 has been shown to mitigate TNFα-mediated insulin resistance in mature adipocytes[1].
In vivo	LG100754 (100 mg/kg) fully blocks the enhance in glucose levels. It also shows that LG100754 can improve insulin resistance in vivo[1].
Synonyms	UVI 2112

Chemical Properties

Molecular Weight	396.56
Formula	C₂₆H₃₆O₃
Cas No.	180713-37-5
Smiles	CCCOc1cc2c(cc1\C(C)=C/C=C/C(/C)=C/C(O)=O)C(C)(C)CCC2(C)C
Relative Density.	1.003g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (226.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5217 mL	12.6084 mL	25.2169 mL	126.0843 mL
5 mM	0.5043 mL	2.5217 mL	5.0434 mL	25.2169 mL
10 mM	0.2522 mL	1.2608 mL	2.5217 mL	12.6084 mL
20 mM	0.1261 mL	0.6304 mL	1.2608 mL	6.3042 mL
50 mM	0.0504 mL	0.2522 mL	0.5043 mL	2.5217 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2608 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc