Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling.

PD-1/PD-L1:4.05 μg/mL, PD-1/PD-L1:1.99 μg/mL

METHODS: To study the antitumor activity of Anti-Mouse PD-1 Antibody, mice were subcutaneously injected with MC38 (1×10^6) or B16-hCXCR4 (5×10^5). Two weeks later, tumor-bearing mice were intraperitoneally (ip) treated with anti-PD-1 mouse antibody [RMP1-14] (5 mg/kg, twice a week for 2 weeks), Pep R (2 mg/kg, 5 days a week for 2 weeks), or both.
RESULTS: Combination therapy (Pep R plus anti-PD-1) reduced the relative tumor volume (RTV) of MC38 by 2.67 times (p=0.038), while anti-PD-1 or Pep R alone did not significantly affect tumor growth. [1]