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ABP-102
(Synonyms: CTP72, CT P72, ABP102) Copy Product Info
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Synonyms: CTP72, CT P72, ABP102
Catalog No. T9901A-750 Copy Product Info
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ABP-102 (CT P72) is a tetravalent IgG1-[L]-scFv bispecific t-cell adduct (BiTE) that acts as a CD3 modulator and selective HER2 modulator for the selective targeting of HER2 overexpressing tumors. ABP-102 showed cytotoxicity in HER2-overexpressing models of breast and gastric cancers, while significantly decreasing activity against HER2 low level cells, twice as effective as rununmotamab.
ABP-102
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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| Description | ABP-102 (CT P72) is a tetravalent IgG1-[L]-scFv bispecific t-cell adduct (BiTE) that acts as a CD3 modulator and selective HER2 modulator for the selective targeting of HER2 overexpressing tumors. ABP-102 showed cytotoxicity in HER2-overexpressing models of breast and gastric cancers, while significantly decreasing activity against HER2 low level cells, twice as effective as rununmotamab. |
| In vitro | ABP-102/CT-P72 achieves potent cytotoxicity in HER2-overexpressing breast and gastric cancer models while significantly reducing activity against HER2-low cells, addressing a key limitation of prior HER2-targeted T-cell engagers[1]. ABP-102/CT-P72 achieved up to twice the tumor suppression compared to a biosimilar of runimotamab (a benchmark HER2 x CD3 bispecific antibody)[1].By engineering functionally monovalent CD3 binding, ABP-102/CT-P72 significantly reduced cytokine release in HER2-low models while maintaining strong cytotoxicity in HER2-high models[1]. |
| In vivo | Dose escalation studies in cynomolgus monkeys showed that ABP-102/CT-P72 was well tolerated even at doses over 180 times higher than the maximum tolerated dose of the parental antibody [1]. |
| Synonyms | CTP72, CT P72, ABP102 |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: ABP-102 in vivo | ABP-102 in vitro
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