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Aristolochic acid D
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Catalog No. TN1070Cas No. 17413-38-6
Aristolochic Acid D, a derivative of aristolochic acid isolated from the stems of Aristolochia indica, is identified as both a carcinogen and nephrotoxin.
Aristolochic acid D
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Purity: 99.68%
Catalog No. TN1070Cas No. 17413-38-6
Aristolochic Acid D, a derivative of aristolochic acid isolated from the stems of Aristolochia indica, is identified as both a carcinogen and nephrotoxin.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $106 | - | In Stock | |
| 5 mg | $263 | - | In Stock | |
| 10 mg | $392 | - | In Stock | |
| 25 mg | $645 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $198 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.68%
Appearance:Solid
Color:Orange
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Product Introduction
Aristolochic acid D AI Summary
Aristolochic acid D exhibits multiple bioactivities, notably as an inhibitor of CDK2 with an IC50 value of 25000.0 nM. It also demonstrates significant anti-inflammatory properties in human neutrophils by inhibiting superoxide anion generation and elastase release induced by fMLP/CB, with IC50 values of 5.78 µg/mL and 8.49 µg/mL, respectively, after 5 minutes. Additionally, the compound shows efficacy in inhibiting the formation of the Importin beta complex (28183.8 nM) and inducing the dissociation of the RanGTP-induced Rango (6513.1 nM). It acts against Human Flap endonuclease 1 with an IC50 of 56234.1 nM. Specifically, in cancer-related activities, Aristolochic acid D induces DNA re-replication in MCF 10a normal breast cells and SW480 colon adenocarcinoma cells, with IC50 values of 1458.1 nM and 103.2 nM respectively. Lastly, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells in the absence of CPT with an IC50 of 32642.7 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aristolochic Acid D, a derivative of aristolochic acid isolated from the stems of Aristolochia indica, is identified as both a carcinogen and nephrotoxin. |
| Molecular Weight | 357.27 |
| Formula | C17H11NO8 |
| Cas No. | 17413-38-6 |
| Smiles | COc1cc(O)cc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O |
| Relative Density. | 1.656 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.5 mg/mL (15.39 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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