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Anti-Apolipoprotein H/APOH Antibody (8K845)
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Catalog No. TMAY-01772
Alias BG, B2GP1, B2G1, apolipoprotein H (β-2-glycoprotein I), apolipoprotein H (beta-2-glycoprotein I)
Anti-Apolipoprotein H/APOH Antibody (8K845) is a Mouse antibody targeting Apolipoprotein H/APOH. Anti-Apolipoprotein H/APOH Antibody (8K845) can be used in ELISA(Det).
Anti-Apolipoprotein H/APOH Antibody (8K845)
Anti-Apolipoprotein H/APOH Antibody (8K845)
😃Good
Catalog No. TMAY-01772Alias BG, B2GP1, B2G1, apolipoprotein H (β-2-glycoprotein I), apolipoprotein H (beta-2-glycoprotein I)
Anti-Apolipoprotein H/APOH Antibody (8K845) is a Mouse antibody targeting Apolipoprotein H/APOH. Anti-Apolipoprotein H/APOH Antibody (8K845) can be used in ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | 65 € | 7-10 days | |
| 100 μL | 188 € | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Apolipoprotein H/APOH Antibody (8K845) is a Mouse antibody targeting Apolipoprotein H/APOH. Anti-Apolipoprotein H/APOH Antibody (8K845) can be used in ELISA(Det). |
| Alias | BG, B2GP1, B2G1, apolipoprotein H (β-2-glycoprotein I), apolipoprotein H (beta-2-glycoprotein I) |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8K845 |
| Reactivity | Human |
| Application | ELISA(Det) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Apolipoprotein H (rh Apolipoprotein H; TMPY-01278; NP_000033.2; Met1-Cys345). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. APOH appears to completely inhibit serotonin release by the platelets and prevents subsequent waves of the ADP-induced aggregation. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway. APOH causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of APOH suggesting a regulatory role of APOH in coagulation. APOH plasma concentrations are strongly associated to metabolic syndrome alterations and vascular disease in type 2 diabetic and could be considered as a clinical marker of cardiovascular risk. APOH is found on several classes of lipoproteins, and is involved in the activation of lipoprotein lipase in lipid metabolism. This single-chain glycoprotein also has been implicated in several physiologic pathways including coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH). |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Apolipoprotein H Protein (TMPY-01278) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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