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Sonepiprazole
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Catalog No. T23380Cas No. 170858-33-0
Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociation constants (Kis) of 3.6 nM and 10.1 nM for rat D4 (rD4) and human D4.2 (hD4.2) dopamine receptors, respectively; it shows significantly less affinity for rat D2 (rD2) dopamine and Histamine-H1 receptors, with Kis of 5147 nM and 7430 nM, respectively.
Sonepiprazole
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Purity: 99.81%
Catalog No. T23380Cas No. 170858-33-0
Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociation constants (Kis) of 3.6 nM and 10.1 nM for rat D4 (rD4) and human D4.2 (hD4.2) dopamine receptors, respectively; it shows significantly less affinity for rat D2 (rD2) dopamine and Histamine-H1 receptors, with Kis of 5147 nM and 7430 nM, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $37 | In Stock | In Stock | |
| 10 mg | $60 | In Stock | In Stock | |
| 25 mg | $133 | In Stock | In Stock | |
| 50 mg | $226 | In Stock | In Stock | |
| 100 mg | $326 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.81%
Appearance:Solid
Color:White
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Product Introduction
Sonepiprazole AI Summary
Sonepiprazole exhibits a variety of bioactivities, particularly in relation to its binding affinity towards multiple receptors and its potential antipsychotic effects. It shows inhibition of 20.0% on Dopamine receptor D1 and has varying Ki values: over 4300.0 nM for Dopamine receptor D2, 5800.0 nM for Dopamine receptor D3, and 7.2 nM for Dopamine receptor D4. Additionally, it has Ki values over 3700.0 nM for the 5-hydroxytryptamine 1A receptor, over 1800.0 nM for the 5-hydroxytryptamine 2 receptor, over 4900.0 nM for the Alpha-1 adrenergic receptor, and over 2600.0 nM for the Alpha-2 adrenergic receptor. These affinities suggest its potential effects on neurotransmission and related pathways.
Specifically, Sonepiprazole shows antipsychotic potential by mitigating the disruption caused by apomorphine in prepulse inhibition (PPI) after subcutaneous administration at a median effective dose (MED) of 30.0 mg/kg. It exhibits a high binding affinity towards the human dopamine receptor D4 with a dissociation constant (Ki) of 6.8 nM. Although it inhibits the human dopamine D1, D2, D3, D4, and D4.2 receptors, its affinity varies significantly across these receptors. Moreover, it shows inhibition of serotonin 5-HT1A and 5-HT2 receptors, as well as the alpha2A adrenergic receptor and the histamine H1 receptor, but with higher Ki values indicating lower affinity for these receptors compared to the dopamine receptors.
In addition to its effects on neurotransmitter receptors, Sonepiprazole also exhibits antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in VERO-6 cells, though with an IC50 value greater than 20000.0 nM, indicating relatively weak potency in this assay..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociation constants (Kis) of 3.6 nM and 10.1 nM for rat D4 (rD4) and human D4.2 (hD4.2) dopamine receptors, respectively; it shows significantly less affinity for rat D2 (rD2) dopamine and Histamine-H1 receptors, with Kis of 5147 nM and 7430 nM, respectively. |
| Targets&IC50 | D2 receptor (rat):5147 nM (Ki), D4 receptor (human):10.1 nM (Ki), H1 receptor:7430 nM (Ki), D4 receptor (rat):3.6 nM (Ki) |
| Molecular Weight | 401.52 |
| Formula | C21H27N3O3S |
| Cas No. | 170858-33-0 |
| Smiles | C(CN1CCN(CC1)C2=CC=C(S(N)(=O)=O)C=C2)[C@H]3C=4C(CCO3)=CC=CC4 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (149.43 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.98 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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