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Isosorbide

Name: Isosorbide
Brand: TargetMol
SKU: T6551
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6551Cas No. 652-67-5

Alias Isobide, Hydronol, D-Isosorbide, Dianhydro-D-glucitol, Devicoran

Isosorbide (Devicoran) is a heterocyclic compound that is derived from glucose, used as a diuretic.

Isosorbide

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Purity: 97.28%

Catalog No. T6551Alias Isobide, Hydronol, D-Isosorbide, Dianhydro-D-glucitol, DevicoranCas No. 652-67-5

Isosorbide (Devicoran) is a heterocyclic compound that is derived from glucose, used as a diuretic.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.28%

Appearance:Viscous

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Isosorbide (Devicoran) is a heterocyclic compound that is derived from glucose, used as a diuretic.
In vitro	Isosorbide increases urine volume by increasing the amount of osmotically active solute in the urine. Osmotic diuretics also increase the osmolarity of plasma. Isosorbide is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased. [1]
Synonyms	Isobide, Hydronol, D-Isosorbide, Dianhydro-D-glucitol, Devicoran

Chemical Properties

Molecular Weight	146.14
Formula	C₆H₁₀O₄
Cas No.	652-67-5
Smiles	O[C@@H]1[C@@]2([C@@]([C@H](O)CO2)(OC1)[H])[H]
Relative Density.	1.0945 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (342.14 mM), Sonication is recommended.

H2O: 100 mg/mL (684.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.8428 mL	34.2138 mL	68.4275 mL	342.1377 mL
5 mM	1.3686 mL	6.8428 mL	13.6855 mL	68.4275 mL
10 mM	0.6843 mL	3.4214 mL	6.8428 mL	34.2138 mL
20 mM	0.3421 mL	1.7107 mL	3.4214 mL	17.1069 mL
50 mM	0.1369 mL	0.6843 mL	1.3686 mL	6.8428 mL
100 mM	0.0684 mL	0.3421 mL	0.6843 mL	3.4214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc