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Ginkgolic Acid

Name: Ginkgolic Acid
Brand: TargetMol
SKU: T6S2123
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S2123Cas No. 22910-60-7

Alias Romanicardic acid, Ginkgolic acid I, Ginkgolic acid C15:1, Ginkgolic acid (15:1)

Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.

Ginkgolic Acid

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Purity: 99.9%

Catalog No. T6S2123Alias Romanicardic acid, Ginkgolic acid I, Ginkgolic acid C15:1, Ginkgolic acid (15:1)Cas No. 22910-60-7

Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$163	In Stock	In Stock
100 mg	$239	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$60	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.9%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Ginkgolic Acid AI Summary

Ginkgolic Acid exhibits a range of bioactivities across various biological targets. It has demonstrated antibacterial activity against Streptococcus mutans ATCC 25175 and Propionibacterium acnes ATCC 11827, with a Minimum Inhibitory Concentration (MIC) of 6.25 μg/mL and 0.78 μg/mL respectively. It inhibits soybean lipoxygenase-1 with an IC50 of 50000.0 nM and human tissue factor/human factor 7a with an IC50 of 32000.0 nM. In assays related to cancer, Ginkgolic Acid shows growth inhibition of several human cancer cell lines (MCF7, HCT15, A549, HT1197, SKOV3) with IC50 values varying from nanomolar to microgram per milliliter concentrations. The compound inhibits mushroom tyrosinase by 15.0% at 0.8 mM and has an ID50 of 7.5 mM for the same enzyme's activity. Moreover, Ginkgolic Acid inhibits several other enzymes and processes including HSD17B4 (IC50: 79432.8 nM), JMJD2E, Cruzain, Tau fibril formation, 15-hLO, Fructose-1,6-bisphosphate Aldolase, GCN5L2, 15-hLO-2, VDR, Polymerase Kappa, USP1/UAF1, and TDP1, with respective potencies ranging from 1584.9 nM to 79432.8 nM. It also inhibits recombination SAE1-mediated SUMOylation of RanGAP1-C2 with an IC50 of 3000.0 nM, and MMP2 (IC50: 6300.0 nM). In behavioral studies, it deters the feeding behavior of Cydia pomonella (codling moth) neonates when infested in apple fruit plugs. Additionally, it inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells with 135.86% and 93.22% inhibition, respectively, at 10 μM. Furthermore, Ginkgolic Acid acts as an inhibitor of both SMS1 and SMS2 enzymes with an IC50 value of 1500.0 nM for each, and inhibits the SUMOylation of RanGAP1-C-terminal fragment by mediating Ubc9 and SUMO interaction inhibition with an IC50 of 3000.0 nM. It has a LogP value of 3.99, indicating its partition coefficient, and shows limited inhibition of pig pancreatic trypsin with an IC50 greater than 200,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.
Targets&IC50	SUMOylation:3.0 μM (IC50)
Synonyms	Romanicardic acid, Ginkgolic acid I, Ginkgolic acid C15:1, Ginkgolic acid (15:1)

Chemical Properties

Molecular Weight	346.50
Formula	C₂₂H₃₄O₃
Cas No.	22910-60-7
Smiles	CCCCCC\C=C/CCCCCCCc1cccc(O)c1C(O)=O
Relative Density.	1.014 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 34.70 mg/mL (100.14 mM), Sonication is recommended.

DMSO: 245.00 mg/mL (707.07 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Saline: 1.50 mg/mL (4.33 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8860 mL	14.4300 mL	28.8600 mL	144.3001 mL
5 mM	0.5772 mL	2.8860 mL	5.7720 mL	28.8600 mL
10 mM	0.2886 mL	1.4430 mL	2.8860 mL	14.4300 mL
20 mM	0.1443 mL	0.7215 mL	1.4430 mL	7.2150 mL
50 mM	0.0577 mL	0.2886 mL	0.5772 mL	2.8860 mL
100 mM	0.0289 mL	0.1443 mL	0.2886 mL	1.4430 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc