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DDR Inhibitor

Name: DDR Inhibitor
Brand: TargetMol
SKU: T10985
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10985Cas No. 1644069-80-6

DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM.

DDR Inhibitor

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Purity: 99.61%

Catalog No. T10985Cas No. 1644069-80-6

DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$397	In Stock	In Stock
25 mg	$798	In Stock	In Stock
50 mg	$1,270	In Stock	In Stock
100 mg	$1,720	-	In Stock
1 mL x 10 mM (in DMSO)	$273	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.61%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM.
Targets&IC50	DDR2:3.3 nM , DDR1:1.5 nM (IC53)
In vitro	DDR inhibitor is an effective DDR inhibitor. The IC50 of DDR2 is 3.3 nM, which has 53% inhibition on DDR1 at 1.5 nM.

Chemical Properties

Molecular Weight	417.44
Formula	C₂₃H₂₀FN₅O₂
Cas No.	1644069-80-6
Smiles	Cc1ccc(CNC(=O)Nc2cccc(F)c2)cc1NC(=O)c1cnc2ccccn12
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (119.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3956 mL	11.9778 mL	23.9555 mL	119.7777 mL
5 mM	0.4791 mL	2.3956 mL	4.7911 mL	23.9555 mL
10 mM	0.2396 mL	1.1978 mL	2.3956 mL	11.9778 mL
20 mM	0.1198 mL	0.5989 mL	1.1978 mL	5.9889 mL
50 mM	0.0479 mL	0.2396 mL	0.4791 mL	2.3956 mL
100 mM	0.0240 mL	0.1198 mL	0.2396 mL	1.1978 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc