NSC23925

Name: NSC23925
Brand: TargetMol
SKU: T16352
Rating: 4.5 (1 reviews)

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Catalog No. T16352Cas No. 858474-14-3

NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).

NSC23925

🥰Excellent

Catalog No. T16352Cas No. 858474-14-3

NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).

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Product Introduction

Bioactivity

Description	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
In vitro	NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. SKOV-3 cells with long-term exposure of 1 μM NSC23925 display stable growth in the culture medium. However, the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3TR or OVCAR8TR to cytotoxic drugs is 0.5 μM to 1 μM. The IC50 for NSC23925 is 8 μM in SKOV-3/SKOV-3TR and 25 μM in OVCAR8/OVCAR8TR cell lines. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 μM [1][2].
In vivo	The usage of NSC23925 significantly prolongs the anticancer efficacy of paclitaxel in paclitaxel chemotherapy. Both saline alone and NSC23925 alone treated tumors grow progressively [1].

Chemical Properties

Molecular Weight	421.36
Formula	C₂₂H₂₆Cl₂N₂O₂
Cas No.	858474-14-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc