NSC23925

Name: NSC23925
Brand: TargetMol
SKU: T16352
Rating: 4.5 (1 reviews)

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Catalog No. T16352Cas No. 858474-14-3

NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).

NSC23925

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Catalog No. T16352Cas No. 858474-14-3

NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).

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Product Introduction

Bioactivity

Description	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
In vitro	NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. SKOV-3 cells with long-term exposure of 1 μM NSC23925 display stable growth in the culture medium. However, the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3TR or OVCAR8TR to cytotoxic drugs is 0.5 μM to 1 μM. The IC50 for NSC23925 is 8 μM in SKOV-3/SKOV-3TR and 25 μM in OVCAR8/OVCAR8TR cell lines. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 μM [1][2].
In vivo	The usage of NSC23925 significantly prolongs the anticancer efficacy of paclitaxel in paclitaxel chemotherapy. Both saline alone and NSC23925 alone treated tumors grow progressively [1].

Chemical Properties

Molecular Weight	421.36
Formula	C₂₂H₂₆Cl₂N₂O₂
Cas No.	858474-14-3
Smiles	Cl.Cl.COc1ccc(cc1)-c1cc(C(O)C2CCCCN2)c2ccccc2n1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc