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TLR7 agonist 2

Name: TLR7 agonist 2
Brand: TargetMol
SKU: T4258
Price: 94 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4258Cas No. 1642857-69-9

Alias TLR7-IN-1, TLR7-agonist-1

TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).

TLR7 agonist 2

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Purity: 99.33%

Catalog No. T4258Alias TLR7-IN-1, TLR7-agonist-1Cas No. 1642857-69-9

TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$94	In Stock	In Stock
5 mg	$238	In Stock	In Stock
10 mg	$332	In Stock	In Stock
25 mg	$559	In Stock	In Stock
50 mg	$768	In Stock	In Stock
100 mg	$1,060	-	In Stock
1 mL x 10 mM (in DMSO)	$231	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.33%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
Targets&IC50	TLR7:LEC: 0.4 μM
Cell Research	The ability of TLR7-agonist-1 to activate human TLR7 and/or TLR8 is assessed by using HEK293 cells. Briefly, HEK293 cells are grown in culture medium (DMEM supplemented with 10% FCS and 2 mM Glutamine). Transfected cells are then detached with Trypsin-EDTA, washed in PBS and resuspended in medium to a density of 1.67×105 cells/mL. Thirty microliters of cells are then dispensed into each well in 384-well plates, where 10 μL of TLR7-agonist-1 in 4% DMSO is already present. Following 6 hours incubation at 37°C, 5% CO2, the luciferase activity is determined by adding 15 μL of Steady Lite Plus substrate to each well and readout performed on a microplate imager. Lowest effective concentrations (LEC) values are determined for TLR7-agonist-1.
Animal Research	In C57Bl/6 mice model,Single oral administration of 0.3, 1, 3, and 10 mg/kg doses of TLR7-agonist-1.
Synonyms	TLR7-IN-1, TLR7-agonist-1

Chemical Properties

Molecular Weight	336.35
Formula	C₁₇H₁₆N₆O₂
Cas No.	1642857-69-9
Smiles	Cc1cc(COc2nc(N)nc3ccn(Cc4ccccn4)c23)no1
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (133.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9731 mL	14.8655 mL	29.7309 mL	148.6547 mL
5 mM	0.5946 mL	2.9731 mL	5.9462 mL	29.7309 mL
10 mM	0.2973 mL	1.4865 mL	2.9731 mL	14.8655 mL
20 mM	0.1487 mL	0.7433 mL	1.4865 mL	7.4327 mL
50 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9731 mL
100 mM	0.0297 mL	0.1487 mL	0.2973 mL	1.4865 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc