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NBDHEX

Name: NBDHEX
Brand: TargetMol
SKU: T12189
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12189Cas No. 787634-60-0

NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

NBDHEX

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Purity: 97.38%

Catalog No. T12189Cas No. 787634-60-0

NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$192	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$463	-	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.38%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
In vitro	NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC(50) of 2.3 +/- 0.6 micromol/L) but also overcomes the multidrug resistance of its variant, H69AR, which overexpresses the ATP-binding cassette transporter multidrug resistance-associated protein 1 (MRP1;?LC(50) of 4.5 +/- 0.9 micromol/L).?Drug efflux experiments, done in the presence of a specific inhibitor of MRP1, confirmed that NBDHEX is not a substrate for this export pump [1].
In vivo	NBDHEX, In female mice, treatment results in a statistically significant tumour inhibition (approximately 70%) [1].

Chemical Properties

Molecular Weight	297.33
Formula	C₁₂H₁₅N₃O₄S
Cas No.	787634-60-0
Smiles	N(=O)(=O)C=1C=2C(C(SCCCCCCO)=CC1)=NON2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (420.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3633 mL	16.8163 mL	33.6327 mL	168.1633 mL
5 mM	0.6727 mL	3.3633 mL	6.7265 mL	33.6327 mL
10 mM	0.3363 mL	1.6816 mL	3.3633 mL	16.8163 mL
20 mM	0.1682 mL	0.8408 mL	1.6816 mL	8.4082 mL
50 mM	0.0673 mL	0.3363 mL	0.6727 mL	3.3633 mL
100 mM	0.0336 mL	0.1682 mL	0.3363 mL	1.6816 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc