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Atrimustine

Name: Atrimustine
Brand: TargetMol
SKU: T14344
Rating: 4.5 (1 reviews)

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Catalog No. T14344Cas No. 75219-46-4

Alias KM2210, Bestrabucil

Atrimustine, a conjugate of chlorambucil and β-estradiol benzoate, possesses antitumor activity.

Atrimustine

😃Good

Catalog No. T14344Alias KM2210, BestrabucilCas No. 75219-46-4

Atrimustine, a conjugate of chlorambucil and β-estradiol benzoate, possesses antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$916	6-8 weeks	6-8 weeks
50 mg	$1,190	6-8 weeks	6-8 weeks
100 mg	$1,860	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Atrimustine, a conjugate of chlorambucil and β-estradiol benzoate, possesses antitumor activity.
In vitro	Atrimustine (Bestrabucil), a conjugate combining chlorambucil with β-estradiol benzoate, exhibits a high affinity for tumor cells, thereby boosting the antitumor efficacy of chlorambucil[1]. This compound demonstrates concentration-dependent inhibition of growth factor production in Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cancer cell line, across a range of 100 nM to 10 μM. This inhibition is evidenced through a 3H-thymidine uptake assay[2], highlighting Atrimustine's potential in hindering cancer cell proliferation.
Synonyms	KM2210, Bestrabucil

Chemical Properties

Molecular Weight	720.72
Formula	C₄₁H₄₇Cl₂NO₆
Cas No.	75219-46-4
Relative Density.	1.1424 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KM 2210AtrimustineKM-2210