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Gentiopicroside

Name: Gentiopicroside
Brand: TargetMol
SKU: T2770
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2770Cas No. 20831-76-9

Alias Gentiopicrin

Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatoryand antioxidative effects.

Gentiopicroside

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Purity: 99.99%

Catalog No. T2770Alias GentiopicrinCas No. 20831-76-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$106	In Stock	In Stock
50 mg	$172	In Stock	In Stock
100 mg	$278	In Stock	In Stock
200 mg	$417	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Gentiopicroside AI Summary

Gentiopicroside exhibits a range of bioactivities across various biological systems. It has antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 with an IC50 greater than 50.0 µg/mL, indicating limited efficacy at lower concentrations. The compound demonstrates significant mutagenic potential in several Salmonella strains (TA97a, TA98, TA100, TA102) based on the Ames test, with revertant counts ranging from 19.0 to 413.0 across concentrations from 40 to 100 µg/plate, both in the presence and absence of the S9 fraction. In cytotoxicity assays, it maintains a cell viability of 95.0% in CHO cells after 2 hours based on the WST1 test. Additionally, Gentiopicroside inhibits the delayed death of the malaria plastid, HP1-beta Chromodomain interactions with methylated histone tails, TGF-b, and USP1/UAF1 with potencies ranging from 891.3 nM to 100000.0 nM. The compound shows antiviral activities, including inhibition of HCV pseudoparticle entry into human Huh7 cells with minimal inhibition percentages at 1 µM and 5 µM, and inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM, with inhibition rates of 4.88% and -0.02% respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease by 9.468% at 20 µM concentration. Furthermore, Gentiopicroside demonstrates anti-adipogenic properties by significantly inhibiting lipid accumulation and pre-adipocyte differentiation in mouse 3T3L1 cells, showing inhibition rates of up to 64.0% and 72.0% respectively. Finally, it shows variable inhibition of human HDAC6 enzyme activity, with -19.99% inhibition using a commercial peptide substrate and 2.71% inhibition with a custom peptide substrate, suggesting potential as an HDAC6 inhibitor that warrants further investigation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatoryand antioxidative effects.
Targets&IC50	CYPP450:61 μM
Synonyms	Gentiopicrin

Chemical Properties

Molecular Weight	356.32
Formula	C₁₆H₂₀O₉
Cas No.	20831-76-9
Smiles	OC[C@H]1O[C@@H](O[C@@H]2OC=C3C(=O)OCC=C3[C@H]2C=C)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.52 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (701.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8065 mL	14.0323 mL	28.0647 mL	140.3233 mL
5 mM	0.5613 mL	2.8065 mL	5.6129 mL	28.0647 mL
10 mM	0.2806 mL	1.4032 mL	2.8065 mL	14.0323 mL
20 mM	0.1403 mL	0.7016 mL	1.4032 mL	7.0162 mL
50 mM	0.0561 mL	0.2806 mL	0.5613 mL	2.8065 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4032 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc