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UCM-1306

Catalog No. T67729 CAS 2258608-78-3

UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamine (DA) both in human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD).

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UCM-1306, CAS 2258608-78-3

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Purity: 98%

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Description	UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamine (DA) both in human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD).
In vitro	UCM-1306 (1-10 μM) enhances CAMP in a concentration-response manner, EC50=60 nM[1].
In vivo	UCM-1306 (p.o.; C57BL/6J mice) has good brain penetration and oral availability. The plasma concentration can be quantified within 8 hours, and Tmax is 0.5 hours. UCM-1306 (1 mg/kg; ip) enhances cocaine induced hyperactivity in adult mice. UCM-1306 (1 mg/kg; ip) helps to consolidate the formation of long-term memory [1].

Molecular Weight	279.33
Formula	C14H14FNO2S
CAS No.	2258608-78-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45.0 mg/mL (161.1 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. García-Cárceles J, et, al. 2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65(18):12256-12272.

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Keywords

UCM-1306 2258608-78-3 GPCR/G Protein Neuroscience Dopamine Receptor UCM1036 Inhibitor inhibitor inhibit

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