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Ningetinib

Name: Ningetinib
Brand: TargetMol
SKU: TQ0021
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0021Cas No. 1394820-69-9

Alias CT053PTSA, CT-053

Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.

Ningetinib

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Purity: 99.98%

Catalog No. TQ0021Alias CT053PTSA, CT-053Cas No. 1394820-69-9

Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.

Pack Size	Price	Availability
2 mg	$42	In Stock
5 mg	$68	In Stock
10 mg	$97	In Stock
25 mg	$198	In Stock
50 mg	$343	In Stock
100 mg	$587	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Purity:99.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
Targets&IC50	VEGFR2:1.9 nM (cell free), Axl:<1 nM (cell free), c-Met:6.7 nM (cell free)
In vitro	In cell-based functional assays, Ningetinib inhibits VEGF and HGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 6.3 and 8.6 nM, respectively.
In vivo	In the orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time and yields a significant increase in life-span value (ILS=32%) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group. When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues.
Synonyms	CT053PTSA, CT-053

Chemical Properties

Molecular Weight	556.58
Formula	C₃₁H₂₉FN₄O₅
Cas No.	1394820-69-9
Smiles	Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Relative Density.	1.348 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (26.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7967 mL	8.9834 mL	17.9669 mL	89.8343 mL
5 mM	0.3593 mL	1.7967 mL	3.5934 mL	17.9669 mL
10 mM	0.1797 mL	0.8983 mL	1.7967 mL	8.9834 mL
20 mM	0.0898 mL	0.4492 mL	0.8983 mL	4.4917 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc