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ST034307

Name: ST034307
Brand: TargetMol
SKU: T16938
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16938Cas No. 133406-29-8

ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).

ST034307

🥰Excellent

Purity: 99.28%

Catalog No. T16938Cas No. 133406-29-8

ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).

Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$74	In Stock
10 mg	$117	In Stock
25 mg	$248	In Stock
50 mg	$412	In Stock
100 mg	$632	In Stock
200 mg	$897	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Purity:99.28%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
Targets&IC50	AC type I:2.3 μM
In vitro	ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1].
In vivo	ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice [1].

Chemical Properties

Molecular Weight	297.95
Formula	C₁₀H₄Cl₄O₂
Cas No.	133406-29-8
Smiles	Clc1ccc2oc(cc(=O)c2c1)C(Cl)(Cl)Cl
Relative Density.	1.674 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (167.81 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3563 mL	16.7813 mL	33.5627 mL	167.8134 mL
5 mM	0.6713 mL	3.3563 mL	6.7125 mL	33.5627 mL
10 mM	0.3356 mL	1.6781 mL	3.3563 mL	16.7813 mL
20 mM	0.1678 mL	0.8391 mL	1.6781 mL	8.3907 mL
50 mM	0.0671 mL	0.3356 mL	0.6713 mL	3.3563 mL
100 mM	0.0336 mL	0.1678 mL	0.3356 mL	1.6781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc