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lutidinic acid

Name: lutidinic acid
Brand: TargetMol
SKU: T2167
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2167Cas No. 499-80-9

Alias 2,4-Pyridinedicarboxylic acid, 2,4-PDCA, 2,4-Dicarboxypyridine, 2, 4-PDCA

lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.

lutidinic acid

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Purity: 98.06%

Catalog No. T2167Alias 2,4-Pyridinedicarboxylic acid, 2,4-PDCA, 2,4-Dicarboxypyridine, 2, 4-PDCACas No. 499-80-9

lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.06%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

lutidinic acid AI Summary

lutidinic acid exhibits a broad spectrum of bioactivity, demonstrating significant inhibition across various enzymes, proteins, and biological processes. It showcases an inhibitory effect against vesicular glutamate transport in synaptic vesicles from rat forebrain, achieving 92.0% activity. Additionally, it targets multiple metallo beta-lactamases such as IMP1, VIM2, and FEZ1, with inhibition rates ranging from 65.0% to 98.0%. The compound also impacts several human enzymes, including the 2-oxoglutarate-dependent JMJD2E enzyme (IC50: 4700.0 to 1400.0 nM), human collagen prolyl-4-hydroxylase (Ki: 2000.0 nM), and PHD2 enzyme (IC50: 2000.0 to 1910.0 nM). It modulates epigenetic regulation by affecting KDM4C (IC50: 19.0 nM), JMJD2A (IC50: 700.0 nM), and KDM5B catalytic core (IC50: 3000.0 nM). In addition, it has shown antiviral activity by inhibiting the SARS-CoV-2 3CL-Pro protease by 19.55% at 20 µM. The compound demonstrates diverse inhibitory effects, including against FIH (IC50: 1100.0 nM), ALDH1A1 (IC50: 1412.5 nM), and ALKBH5 (IC50: 9430.0 nM), suggesting potential therapeutic applications across various biological pathways and conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.
Synonyms	2,4-Pyridinedicarboxylic acid, 2,4-PDCA, 2,4-Dicarboxypyridine, 2, 4-PDCA

Chemical Properties

Molecular Weight	167.12
Formula	C₇H₅NO₄
Cas No.	499-80-9
Smiles	C(O)(=O)C=1C=C(C(O)=O)N=CC1
Relative Density.	1.551 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (179.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9837 mL	29.9186 mL	59.8372 mL	299.1862 mL
5 mM	1.1967 mL	5.9837 mL	11.9674 mL	59.8372 mL
10 mM	0.5984 mL	2.9919 mL	5.9837 mL	29.9186 mL
20 mM	0.2992 mL	1.4959 mL	2.9919 mL	14.9593 mL
50 mM	0.1197 mL	0.5984 mL	1.1967 mL	5.9837 mL
100 mM	0.0598 mL	0.2992 mL	0.5984 mL	2.9919 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc