Shopping Cart
- Remove All
- Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $42 | In Stock | |
5 mg | $66 | In Stock | |
10 mg | $123 | In Stock | |
25 mg | $196 | In Stock | |
50 mg | $315 | In Stock | |
100 mg | $509 | In Stock | |
1 mL x 10 mM (in DMSO) | $103 | In Stock |
Description | Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells. |
Targets&IC50 | IDH1 (R132H):12 nM |
In vitro | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1]. |
Cell Research | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference) |
Alias | AG-120 |
Molecular Weight | 582.96 |
Formula | C28H22ClF3N6O3 |
Cas No. | 1448347-49-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 100 mg/mL (171.54 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (85.77 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.