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Ivosidenib

Ivosidenib
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
Catalog No. T3617Cas No. 1448347-49-6
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Purity:100%
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Ivosidenib

Catalog No. T3617Cas No. 1448347-49-6

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
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Pack SizePriceAvailabilityQuantity
2 mg$42In Stock
5 mg$66In Stock
10 mg$123In Stock
25 mg$196In Stock
50 mg$315In Stock
100 mg$509In Stock
1 mL x 10 mM (in DMSO)$103In Stock
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Product Introduction

Bioactivity
Description
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
Targets&IC50
IDH1 (R132H):12 nM
In vitro
TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1].
Cell Research
TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference)
AliasAG-120
Chemical Properties
Molecular Weight582.96
FormulaC28H22ClF3N6O3
Cas No.1448347-49-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 100 mg/mL (171.54 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (85.77 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.7154 mL8.5769 mL17.1538 mL85.7692 mL
5 mM0.3431 mL1.7154 mL3.4308 mL17.1538 mL
10 mM0.1715 mL0.8577 mL1.7154 mL8.5769 mL
20 mM0.0858 mL0.4288 mL0.8577 mL4.2885 mL
50 mM0.0343 mL0.1715 mL0.3431 mL1.7154 mL
Ethanol
1mg5mg10mg50mg
100 mM0.0172 mL0.0858 mL0.1715 mL0.8577 mL

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