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Bersiporocin

😃Good
Catalog No. T39739Cas No. 2241808-52-4
Alias DWN12088, DWN 12088

Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis and is well tolerated in the clinic. In cellular and animal models of idiopathic pulmonary fibrosis (IPF), DWN12088 significantly reduced collagen synthesis and improved lung function.

Bersiporocin

Bersiporocin

😃Good
Purity: 99.79%
Catalog No. T39739Alias DWN12088, DWN 12088Cas No. 2241808-52-4
Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis and is well tolerated in the clinic. In cellular and animal models of idiopathic pulmonary fibrosis (IPF), DWN12088 significantly reduced collagen synthesis and improved lung function.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$475-In Stock
5 mg$1,430-In Stock
10 mg$2,380-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.79%
ee:100%
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COA CSFC HNMR LCMS

Product Introduction

Bioactivity
Description
Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis and is well tolerated in the clinic. In cellular and animal models of idiopathic pulmonary fibrosis (IPF), DWN12088 significantly reduced collagen synthesis and improved lung function.
Targets&IC50
PRS:≤100 nM
SynonymsDWN12088, DWN 12088
Chemical Properties
Molecular Weight328.24
FormulaC15H19Cl2N3O
Cas No.2241808-52-4
SmilesC(CC[C@@H]1[C@@H](O)CCCN1)N2C=3C(N=C2)=C(Cl)C(Cl)=CC3
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (304.66 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 3.3 mg/mL (10.05 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0466 mL15.2328 mL30.4655 mL152.3276 mL
5 mM0.6093 mL3.0466 mL6.0931 mL30.4655 mL
10 mM0.3047 mL1.5233 mL3.0466 mL15.2328 mL
20 mM0.1523 mL0.7616 mL1.5233 mL7.6164 mL
50 mM0.0609 mL0.3047 mL0.6093 mL3.0466 mL
100 mM0.0305 mL0.1523 mL0.3047 mL1.5233 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Bersiporocin
Related Tags: buy Bersiporocin | purchase Bersiporocin | Bersiporocin cost | order Bersiporocin | Bersiporocin chemical structure | Bersiporocin formula | Bersiporocin molecular weight
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