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Anti-Caspase-3 Antibody (1F439)
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Catalog No. TMAC-03427
Alias Yama, SCA-1, CPP32B, CPP32, apopain
Anti-Caspase-3 Antibody (1F439) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (1F439) can be used in FCM,ICC/IF,IHC,IP,WB.
Anti-Caspase-3 Antibody (1F439)
Anti-Caspase-3 Antibody (1F439)
😃Good
Catalog No. TMAC-03427Alias Yama, SCA-1, CPP32B, CPP32, apopain
Anti-Caspase-3 Antibody (1F439) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (1F439) can be used in FCM,ICC/IF,IHC,IP,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Chemical Properties
| Description | Anti-Caspase-3 Antibody (1F439) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (1F439) can be used in FCM,ICC/IF,IHC,IP,WB. |
| Synonyms | Yama, SCA-1, CPP32B, CPP32, apopain |
| Ig Type | IgG |
| Clone | 1F439 |
| Reactivity | Human,Mouse |
| Verified Activity | 1. Western blot analysis of pro Caspase 3 expression in Jurkat cell lysate. 2. All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature. 3. Immunohistochemical analysis of paraffin-embedded human colon, using pro Caspase 3 Antibody. 4. Immunofluorescent analysis of Hela cells, using pro Caspase 3 Antibody. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:100-200; ICC/IF: 1:50-200; IP: 1:20-50; FCM: 1:20-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Research Background | Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system. |
| Conjucates | Unconjugated |
| Immunogen | A synthesized peptide: human Caspase 3 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 35 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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