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Trofinetide (Synonyms: NNZ-2566)

Name: Trofinetide
Brand: TargetMol
SKU: T17171
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T17171 Copy Product Info

Purity: 99.78%

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Trofinetide (NNZ-2566) is a synthetic analog of the endogenous N-terminus tripeptide. It has been shown to be neuroprotective in animal models of brain injury.

Trofinetide

Copy Product Info

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Catalog No. T17171

Synonyms NNZ-2566

Trofinetide (NNZ-2566) is a synthetic analog of the endogenous N-terminus tripeptide. It has been shown to be neuroprotective in animal models of brain injury.

Cas No. 853400-76-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$31	In Stock	In Stock
5 mg	$71	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$243	In Stock	In Stock
50 mg	$388	In Stock	In Stock
100 mg	$619	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.78%

Color:White

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COA LCMS MS

Product Introduction

Bioactivity

Description	Trofinetide (NNZ-2566) is a synthetic analog of the endogenous N-terminus tripeptide. It has been shown to be neuroprotective in animal models of brain injury.
In vivo	Trofinetide treatment suppresses IL-1β expression in the injured brain hemisphere for up to 7 days post-PBBI. Trofinetide suppresses penetrating ballistic-like brain injury-induced inflammatory cell infiltration at 3 days following PBBI as compared to vehicle treatment. All doses of Trofinetide completely suppress the delayed occurrence of NCS as compare with the vehicle-treated animals. Trofinetide treatment produces significant reductions in the injury-induced up-regulation of IL-1β, INF-γ, and TNF-α expression. Trofinetide treatment significantly decreases the elevation of IL-6 (79%), E-selectin (81%), IL-1β (76%), and TNF-α (72%) mRNA levels in the injured hemisphere at 12 h post-PBBI, with maximal inhibition occurring between 12 h and 24 h. The high doses of Trofinetide (10 and 100 mg/kg bolus followed by continuous infusion) attenuate non-convulsive seizure (NCS) occurring beyond 2 h after permanent middle cerebral artery occlusion [1][2].
Synonyms	NNZ-2566

Chemical Properties

Molecular Weight	315.32
Formula	C₁₃H₂₁N₃O₆
Cas No.	853400-76-7
Smiles	C[C@]1(CCCN1C(=O)CN)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Relative Density.	1.377 g/cm3 (Predicted)
Sequence	H-Gly-aMePro-Glu-OH
Sequence Short	GXE

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 44 mg/mL (139.54 mM), Sonication is recommended.

DMSO: 71.43 mg/mL (226.53 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1714 mL	15.8569 mL	31.7138 mL	158.5691 mL
5 mM	0.6343 mL	3.1714 mL	6.3428 mL	31.7138 mL
10 mM	0.3171 mL	1.5857 mL	3.1714 mL	15.8569 mL
20 mM	0.1586 mL	0.7928 mL	1.5857 mL	7.9285 mL
50 mM	0.0634 mL	0.3171 mL	0.6343 mL	3.1714 mL
100 mM	0.0317 mL	0.1586 mL	0.3171 mL	1.5857 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc