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Cytoskeletal SignalingTight Junction Protein
The Tight Junction Protein (TJP) is located at the topmost side of epithelial and endothelial cells. It is composed of transmembrane proteins such as claudin, occludin, JAMs, and cytoplasmic scaffold proteins like ZO-1/2/3. By connecting the actin cytoskeleton, it forms a selective barrier, separating the internal and external environments and maintaining cell polarity. Targeting TJP can repair barrier damage caused by inflammation or tumors, and is a new strategy for the intervention of enteritis, stroke, and tumor metastasis.
Zolbetuximab
T9901A-0051496553-00-4
Zolbetuximab(IMAB362) is a monoclonal antibody that specifically targets Claudin-18.2.Zolbetuximab has potential antitumor activity, mediating killing of Claudin-18.2-positive cells through an immune effector mechanism.Zolbetuximab is used in the study of gastrointestinal adenocarcinomas and pancreatic tumors.
- $263
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Zolbetuximab MMAE
T9901A-222
Zolbetuximab MMAE (IMAB362 MMAE) is a compound targeting Claudin 18.2 (CLDN18.2) with anti-cancer activity, used in the study of gastric and pancreatic cancers.
- $1,690
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Eclutatug
T9901A-389
Eclutatug (ALE C04) is a humanised antibody targeting claudin-1 (CLDN1), which can be used for the treatment of tumours and organ fibrosis indications, such as head and neck squamous cell carcinoma (HNSCC).
- $289
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IMAB027
T782961650599-68-0
IMAB027 (ASP1650) is a selective monoclonal antibody against CLDN6 (Claudin 6) with antitumor activity that induces death of CLDN6+ cancer cells through antibody-dependent and complement-dependent cytotoxicity.
- $298
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Teduglutide acetate
T35337L
Teduglutide acetate, a GLP-2 analogue, maximizes small intestinal mucosal hypertrophy. Teduglutide acetate partially restores small intestinal epithelial function through an altered distribution of claudin-10, facilitating sodium recirculation for Na-coupled glucose transport and water absorption.
- $112
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PDS-0330
T735932904682-19-3
PDS-0330 is a claudin-1 small molecule inhibitor inhibitor.PDS-0330 inhibits claudin-1-dependent CRC progression and binds directly and specifically to claudin-1 with micromolar affinity.PDS-0330 exhibits well characterized pharmacokinetic properties with antitumor and Chemosensitizing activity.PDS-0330 interferes with claudin-1 / Src association to inhibit CRC progression and metastasis.
- $50
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Lixudebart
T819252749515-10-2
Lixudebart is a humanised monoclonal antibody targeting CLDN1 (Claudin-1), which can be used to reverse organ fibrosis (such as pulmonary fibrosis) and reduce initial ALT/AST levels.
- $247
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Osemitamab
T815942460539-61-9
Osemitamab (TST001) is a humanised monoclonal antibody targeting claudin-18.2, composed of a dimer of the γ-1 chain and κ chain of the human-mouse chimeric TST001. It exhibits NK cell-mediated tumour killing activity and is indicated for gastric/gastric-oesophageal junction adenocarcinoma, PDAC, and lung cancer.
- $247
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NSC 357754 dihydrochloride
T207032
NSC 357754 dihydrochloride is an inhibitor of Claudin. It can enhance trans-epithelial electrical resistance and reduce the permeability of specific cations. This compound is useful for research into intestinal diseases mediated by Claudin-2 and/or Claudin-15.
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