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Eptapirone

Name: Eptapirone
Brand: TargetMol
SKU: T3179
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3179Cas No. 179756-58-2

Alias F 11440

Eptapirone (F 11440) is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential.

Eptapirone

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Purity: 99.65%

Catalog No. T3179Alias F 11440Cas No. 179756-58-2

Eptapirone (F 11440) is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$44	In Stock	In Stock
25 mg	$83	In Stock	In Stock
50 mg	$148	In Stock	In Stock
100 mg	$221	In Stock	In Stock
200 mg	$320	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.65%

Color:White

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Product Introduction

Eptapirone AI Summary

Eptapirone displays high affinity for the 5HT1AR receptor with a Ki of 175.0 nM, suggesting potential involvement in serotonin pathways, and exhibits very low affinity for the alpha1 adrenergic receptor with a Ki greater than 10000.0 nM, indicating minimal interaction with adrenergic pathways. The compound demonstrates antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, with measured inhibition of -3.73% and -0.03%, respectively, using high content imaging. Additionally, Eptapirone shows 8.437% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM concentration as determined by a FRET-based assay. The compound also inhibits human HDAC6 activity, showing -47.17% inhibition using a commercial peptide substrate and 8.01% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Eptapirone (F 11440) is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential.
Synonyms	F 11440

Chemical Properties

Molecular Weight	345.4
Formula	C₁₆H₂₃N₇O₂
Cas No.	179756-58-2
Smiles	Cn1c(=O)cnn(CCCCN2CCN(CC2)c2ncccn2)c1=O
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (144.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8952 mL	14.4760 mL	28.9519 mL	144.7597 mL
5 mM	0.5790 mL	2.8952 mL	5.7904 mL	28.9519 mL
10 mM	0.2895 mL	1.4476 mL	2.8952 mL	14.4760 mL
20 mM	0.1448 mL	0.7238 mL	1.4476 mL	7.2380 mL
50 mM	0.0579 mL	0.2895 mL	0.5790 mL	2.8952 mL
100 mM	0.0290 mL	0.1448 mL	0.2895 mL	1.4476 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc