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TargetMol | Compound Library

MAPK Inhibitor Library

Catalog No. L1400

Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs. The MAPK Inhibitor Library by TargetMol, containing 500 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1400

MAPK Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 500 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

Ras
p38 MAPK
ERK
Apoptosis
Autophagy
Raf
MAPK
JNK
MEK
KRas
NF-κB
S6 Kinase
Akt
CDK
TNF
VEGFR
Src
Endogenous Metabolite
Rho
PI3K
MNK
PDGFR
FLT
c-Kit
mTOR
Bcl-2 Family
MLK
Caspase
Aurora Kinase
Antibacterial
Parasite
GSK-3
PKA
Casein Kinase
Ferroptosis
FGFR
TGF-beta/Smad
PKC
COX
STAT
Antifungal
IL Receptor
MMP
Bcr-Abl
ROCK
c-RET
IGF-1R
PARP
Reactive Oxygen Species
ASK
Influenza Virus
FAK
AMPK
EGFR
NO Synthase
Cytochromes P450
DNA/RNA Synthesis
Antiviral
SGK
Tie-2
TOPK
JAK
ALK
IRAK
Antibiotic
TLR
Nrf2
Serine Protease
Trk receptor
c-Fms
KLF
Syk
PYK2
Transferase
Anti-infection
Mitophagy
Calcium Channel
HSP
Tyrosine Kinases
Cholinesterase (ChE)
GPCR
DYRK
GTPase
c-Myc
PAK
HCV Protease
Aryl Hydrocarbon Receptor
P-gp
Tyrosinase
PPAR
Mitochondrial Metabolism
ROS
Chk
Potassium Channel
Histone Methyltransferase
Drug Metabolite
Antifection
Dehydrogenase
Pim
PDK
Epigenetic Reader Domain
AChR
PROTACs
Antioxidant
PERK
Virus Protease
Y Box Binding Protein 1
c-Met/HGFR
BTK
cAMP
Ephrin Receptor
PAI-1
MELK
Aromatase
Sodium Channel
PD-1/PD-L1
MyD88
Glutathione Peroxidase
Phosphatase
Serine/threonin kinase
Topoisomerase
PDE
LDL
PTEN
Prostaglandin Receptor
LRRK2
GPX
RXFP receptor
Cannabinoid Receptor
NADPH-oxidase
p53
Apelin receptor
LIM Kinase
Gamma-secretase
NMDAR
PI4K
HIF/HIF Prolyl-Hydroxylase
Estrogen/progestogen Receptor
RIP kinase
UGT
PGE Synthase
DAPK
Protease-activated Receptor
Kinesin
BACE
IFNAR
Necroptosis
TRP/TRPV Channel
Adrenergic Receptor
ACK1
Lipid
transporter
Beta Amyloid
5-HT Receptor
BMI-1
AhR
Histamine Receptor
AAK1
CSF-1R
Glucosidase
DNA Alkylation
Interleukin
Beta-Secretase
IκB/IKK
ATPase
HBV
Wnt/beta-catenin
iGluR
HSV
GluR
Hippo pathway
Hydroxylase
HER

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