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TOPProduct DescriptionPackaging & StorageSupporting FilesLibrary CustomizationLibrary Composition
TargetMol | Compound Library

MAPK Inhibitor Library

Catalog No. L1400

Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs.

The MAPK Inhibitor Library by TargetMol, containing 861 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1400

MAPK Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 861 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Supporting Files | TargetMol Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (60.2 MB)

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Ras
p38 MAPK
Apoptosis
ERK
NF-κB
JNK
Autophagy
Akt
MAPK
Raf
KRas
ROS
MEK
Endogenous Metabolite
Caspase
S6 Kinase
Interleukin
CDK
Antibacterial
COX
PI3K
NO Synthase
TNF
Src
Bcl-2 Family
VEGFR
mTOR
STAT
PPAR
Rho
DNA/RNA Synthesis
GSK-3
MMP
PKA
PKC
TGF-beta/Smad
Antibiotic
Ferroptosis
PERK
PARP
Parasite
Reactive Oxygen Species
AMPK
Antifungal
Calcium Channel
TLR
Nrf2
MLK
Aurora Kinase
Cytochromes P450
EGFR
Wnt/beta-catenin
Bcr-Abl
PDGFR
MNK
AChR
MDM-2/p53
Casein Kinase
Microtubule Associated
FAK
ROCK
ASK
FLT
c-Kit
Phosphatase
IL Receptor
IGF-1R
HSP
Antioxidant
JAK
Influenza Virus
Beta Amyloid
FGFR
Dehydrogenase
TOPK
GTPase
Immunology/Inflammation related
Cholinesterase (ChE)
ALK
c-RET
Adrenergic Receptor
Mitochondrial Metabolism
cAMP
P-gp
Antiviral
5-HT Receptor
SGK
Potassium Channel
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
ROS Kinase
HIV Protease
PROTACs
Transferase
c-Met/HGFR
Virus Protease
Topoisomerase
Epigenetic Reader Domain
CaMK
Trk receptor
Syk
Sodium Channel
IRAK
GPCR
NOS
Histone Methyltransferase
Histamine Receptor
Tie-2
Mitophagy
c-Myc
HBV
Serine Protease
PYK2
Drug Metabolite
Opioid Receptor
DNA Alkylation
PAK
GluR
LRRK2
IκB/IKK
KLF
Anti-infection
NOD-like Receptor (NLR)
HCV Protease
Integrin
MyD88
DYRK
Tyrosine Kinases
Serine/threonin kinase
TRP/TRPV Channel
Aryl Hydrocarbon Receptor
iGluR
RIP kinase
Gamma-secretase
Antifection
HSV
Chk
Prostaglandin Receptor
SARS-CoV
transporter
PAI-1
c-Fms
GABA Receptor
Cannabinoid Receptor
PD-1/PD-L1
Proteasome
ATPase
Proton pump
Necroptosis
Pim
LIM Kinase
IAP
IRE1
PDE
P2X Receptor
NMDAR
Cadherin
Androgen Receptor
Lipid
OXPHOS
GST
Aromatase
Melanocortin Receptor
PDK
APC/C
HER
Kinesin
BTK
IKZF
Thyroid hormone receptor(THR)
Apelin receptor
Carbonic Anhydrase
DHFR
Piezo Channel
Estrogen/progestogen Receptor
Y Box Binding Protein 1
Arginase
LPL Receptor
DNA Alkylator/Crosslinker
Adenosine Receptor
Arrestin
BACE
Reductase
IFNAR
NADPH
RAAS
Lipase
Glutathione Peroxidase
OCT
Bcl-6
AAK1
ATG
Neurotensin Receptor
FXR
CSF-1R
Prolyl Endopeptidase (PREP)
SIK
E1/E2/E3 Enzyme
UGT
LDL
GRK
ABC Transporter
Glucosidase
DPP-4
Bradykinin Receptor
ACK1
Angiotensin-converting Enzyme (ACE)
PTEN
Xanthine Oxidase
Thrombopoietin Receptor
Lipoxygenase
Norepinephrine
DNA
Telomerase
BCRP
Beta-Secretase
PGE Synthase
Survivin
STING
Sirtuin
Ephrin Receptor
cGAS
Pyroptosis
MELK
Methionine Adenosyltransferase (MAT)
Hippo pathway
p62
GPX
Reverse Transcriptase
Retinoid Receptor
Protease
HDAC
ribosome
PI4K
Phospholipase
Hydroxylase
FOXO
PLK
RXFP receptor
DAPK
Discoidin Domain Receptor (DDR)
BMI-1
NADPH-oxidase
NOD
MAP3K
HMG-CoA Reductase
Tight Junction Protein
Protease-activated Receptor
AhR
p53
PKM
Monoamine Oxidase
S1P Receptor
Vitamin

Keywords

TumorSmall molecule compoundsSignaling cascadeRasRafp38MKKMitogen-activated protein kinaseMEKMAPK signaling pathwayMAPK drug discoveryMAPKKRASKinase inhibitorJNKInhibitor libraryInflammatory diseasesInflammationHigh-throughput screeningERKCompound libraryCellular stressCell proliferationCell differentiationCancerBRAFAutoimmune diseasesATP-competitive
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