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TargetMol | Compound Library

MAPK Inhibitor Library

Catalog No. L1400

Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs.

The MAPK Inhibitor Library by TargetMol, containing 861 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1400

MAPK Inhibitor Library

sizeIn stock

  • 1 mg
  • 10 µL x 10 mM (in DMSO)
  • 20 µL x 10 mM (in DMSO)
  • 30 µL x 10 mM (in DMSO)
  • 50 µL x 10 mM (in DMSO)
  • 100 µL x 10 mM (in DMSO)
  • 250 µL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 861 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Supporting Files | TargetMol Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (60.2 MB)

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Ras
p38 MAPK
Apoptosis
ERK
NF-κB
JNK
Autophagy
Akt
MAPK
Raf
Kras
ROS
MEK
Endogenous Metabolite
Caspase
S6 Kinase
Interleukin
Antibacterial
CDK
COX
PI3K
NO Synthase
TNF
Src
Bcl-2 Family
STAT
mTOR
VEGFR
DNA/RNA Synthesis
Rho
PPAR
MMP
GSK-3
PKC
Ferroptosis
Antibiotic
PKA
TLR
Parasite
PARP
Reactive Oxygen Species
Antifungal
TGF-beta/Smad
AMPK
Nrf2
MLK
Aurora Kinase
Cytochromes P450
EGFR
PERK
Calcium Channel
Bcr-Abl
MDM-2/p53
MNK
Wnt/beta-catenin
PDGFR
AChR
Microtubule Associated
FAK
Casein Kinase
ASK
FLT
c-Kit
Phosphatase
ROCK
IL Receptor
IGF-1R
JAK
HSP
Influenza Virus
Beta Amyloid
Antioxidant
FGFR
Dehydrogenase
GTPase
ALK
Immunology/Inflammation related
Cholinesterase (ChE)
TOPK
c-RET
P-gp
Tyrosinase
Adrenergic Receptor
Antiviral
5-HT Receptor
SGK
cAMP
ROS Kinase
Mitochondrial Metabolism
Potassium Channel
HIF/HIF Prolyl-Hydroxylase
Topoisomerase
Transferase
CaMK
c-Met/HGFR
Sodium Channel
IRAK
Trk receptor
KLF
Syk
PROTACs
Virus Protease
HIV Protease
Epigenetic Reader Domain
Histone Methyltransferase
PYK2
Drug Metabolite
NOS
MyD88
Opioid Receptor
LRRK2
Anti-infection
NOD-like Receptor (NLR)
GPCR
PAK
Serine Protease
HBV
GluR
Histamine Receptor
Tie-2
Mitophagy
DNA Alkylation
IκB/IKK
RIP kinase
Antifection
HCV Protease
Aryl Hydrocarbon Receptor
Prostaglandin Receptor
Cannabinoid Receptor
TRP/TRPV Channel
transporter
DYRK
c-Myc
PAI-1
GABA Receptor
PD-1/PD-L1
Gamma-secretase
Chk
c-Fms
Tyrosine Kinases
iGluR
HSV
Integrin
SARS-CoV
P2X Receptor
Androgen Receptor
Kinesin
Proton pump
Serine/threonin kinase
IRE1
PDE
Cadherin
OXPHOS
Necroptosis
Pim
ACK1
Lipid
PDK
GST
Aromatase
Melanocortin Receptor
NMDAR
ATPase
IAP
HER
Proteasome
APC/C
BTK
IKZF
Estrogen/progestogen Receptor
LPL Receptor
Neurotensin Receptor
UGT
Thrombopoietin Receptor
BCRP
PGE Synthase
Survivin
Methionine Adenosyltransferase (MAT)
DAPK
Discoidin Domain Receptor (DDR)
HMG-CoA Reductase
Protease-activated Receptor
DNA Alkylator/Crosslinker
Arrestin
Glutathione Peroxidase
FXR
Prolyl Endopeptidase (PREP)
LDL
Bradykinin Receptor
PTEN
Xanthine Oxidase
Norepinephrine
STING
Pyroptosis
GPX
Retinoid Receptor
RXFP receptor
NADPH-oxidase
MAP3K
p53
PKM
Piezo Channel
IFNAR
BACE
NADPH
OCT
Bcl-6
GRK
Telomerase
BMI-1
AhR
Monoamine Oxidase
Y Box Binding Protein 1
Arginase
Adenosine Receptor
Lipoxygenase
Ephrin Receptor
MELK
Reverse Transcriptase
NOD
Apelin receptor
Lipase
LIM Kinase
DPP-4
Angiotensin-converting Enzyme (ACE)
Protease
PI4K
PLK
Tight Junction Protein
S1P Receptor
Carbonic Anhydrase
ATG
E1/E2/E3 Enzyme
ABC Transporter
DNA
Sirtuin
cGAS
Hippo pathway
p62
HDAC
ribosome
Hydroxylase
Thyroid hormone receptor(THR)
DHFR
Reductase
CSF-1R
SIK
Glucosidase
Beta-Secretase
Phospholipase
FOXO
Vitamin

Keywords

TumorSmall molecule compoundsSignaling cascadeRasRafp38MKKMitogen-activated protein kinaseMEKMAPK signaling pathwayMAPK drug discoveryMAPKKRASKinase inhibitorJNKInhibitor libraryInflammatory diseasesInflammationHigh-throughput screeningERKCompound libraryCellular stressCell proliferationCell differentiationCancerBRAFAutoimmune diseasesATP-competitive
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