Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
2 mg | In stock | $ 168.00 | |
5 mg | In stock | $ 283.00 | |
10 mg | In stock | $ 422.00 | |
25 mg | In stock | $ 688.00 | |
50 mg | In stock | $ 957.00 | |
100 mg | In stock | $ 1,290.00 |
Description | Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。 |
In vitro | Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1]. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM[2]. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3]. |
In vivo | Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1]. |
Synonyms | Lamuran, Delta-Yohimbine, Raubasine, Ajmalicin |
Molecular Weight | 352.43 |
Formula | C21H24N2O3 |
CAS No. | 483-04-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.5 mg/mL (7.09 mM)
You can also refer to dose conversion for different animals. More
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Ajmalicine 483-04-5 GPCR/G Protein Neuroscience Adrenergic Receptor Lamuran Delta-Yohimbine Raubasine Δ-Yohimbine Ajmalicin inhibitor inhibit