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Dexrazoxane

Name: Dexrazoxane
Brand: TargetMol
SKU: T22305
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22305Cas No. 24584-09-6

Alias ICRF-187

Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

Dexrazoxane

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Purity: 99.88%

Catalog No. T22305Alias ICRF-187Cas No. 24584-09-6

Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

Pack Size	Price	Availability
25 mg	$39	In Stock
50 mg	$57	In Stock
100 mg	$81	In Stock
500 mg	$200	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Batch Information

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Purity:99.88%

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.
Synonyms	ICRF-187

Chemical Properties

Molecular Weight	268.27
Formula	C₁₁H₁₆N₄O₄
Cas No.	24584-09-6
Smiles	C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
Relative Density.	1.333 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 57 mg/mL (212.47 mM), Sonication is recommended.

Methanol: 1.25 mg/mL (4.66 mM), Sonication is recommended.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7276 mL	18.6379 mL	37.2759 mL	186.3794 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.7455 mL	3.7276 mL	7.4552 mL	37.2759 mL
10 mM	0.3728 mL	1.8638 mL	3.7276 mL	18.6379 mL
20 mM	0.1864 mL	0.9319 mL	1.8638 mL	9.3190 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7276 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8638 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc