IFN-beta Protein, Mouse, Recombinant

Name: IFN-beta Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPY-03467
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: interferon, β1, fibroblast, interferon, beta 1, fibroblast, IFN-β, IFN-beta, IFNB, Ifb) Copy Product Info

Synonyms: interferon, β1, fibroblast, interferon, beta 1, fibroblast, IFN-β, IFN-beta, IFNB, Ifb

Catalog No. TMPY-03467 Copy Product Info

Purity: 98.5%

IFN-beta Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.3 kDa and the accession number is P01575.

Pack Size	Price	USA Stock	Global Stock
5 µg	$180	-	In Stock
10 µg	$290	-	In Stock
20 µg	$470	In Stock	In Stock
50 µg	$840	7-10 days	7-10 days
100 µg	$1,350	-	In Stock
200 µg	$2,150	7-10 days	7-10 days
500 µg	$3,860	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.5%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 3-18 pg/mL.
Description	IFN-beta Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.3 kDa and the accession number is P01575.
Species	Mouse
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P01575
Construction	A DNA sequence encoding the mouse IFNB1 (P01575) (Met 1-Asn 182) was fused with five amino acids (DDDDK) at the C-terminus was expressed and purified. Predicted N terminal: Val 19
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	interferon, β1, fibroblast, interferon, beta 1, fibroblast, IFN-β, IFN-beta, IFNB, Ifb
Research Background	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites, and tumor cells. Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or causes autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis and thus has a therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of chronic progressive CNS inflammation.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

20.3 kDa (predicted); 30 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.