TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His)

1. Immobilized Human TNFSF15, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human DR3, hFc Tag with the EC50 of 0.19 μg/ml determined by ELISA. (QC Test)
2. Immobilized Human TNFSF15, His Tag at 1 μg/ml(100 μl/well) on the plate. Dose response curve for Human DcR3, hFc Tag with the EC50 of 24.2 ng/ml determined by ELISA.
3. Immobilized Human TNFSF15, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-TNFSF15 Antibody, hFc Tag with the EC50 of 3.8 ng/ml determined by ELISA
4. Human DR3, hFc Tag captured on CM5 Chip via Protein A can bind Human TNFSF15, His Tag with an affinity constant of 4.09 nM as determined in SPR assay (Biacore T200).
5. Loaded Human DR3, hFc Tag on ProA-Biosensor, can bind Human TNFSF15, His Tag with an affinity constant of 5.04 nM as determined in BLI assay (Gator).

TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is O95150-1.

Human

HEK293 Cells

> 90% as determined by Bis-Tris PAGE

TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.