4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc)

Catalog No. TMPY-06831

4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.41 kDa and the accession number is NP_033430.1.

4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc)

Catalog No. TMPY-06831

4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.41 kDa and the accession number is NP_033430.1.

Pack Size	Price	Availability	Quantity
100 μg	$700	7-10 days
1 mg	$4,560	7-10 days

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Product Information

Biological Activity	Immobilized Recombinant Mouse TNFRSF9 / CD137 / 4-1BB Protein (soluble form, His Tag) at 2μg/mL (100μL/well) can bind Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein (Fc Tag) , the EC50 is 2-6 ng/mL.
Description	4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.41 kDa and the accession number is NP_033430.1.
Species	Mouse
Expression System	HEK293 Cells
Tag	N-hFc
Accession Number	NP_033430.1
Synonyms	tumor necrosis factor (ligand) superfamily, member 9,Ly63l,Cd137l,AI848817,4-1BB-L,4-1BBL
Construction	A DNA sequence encoding the Mouse TNFSF9 (NP_033430.1) (Arg104-Glu309) was expressed with the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Molecular Weight	51.41 kDa (predicted); 60.11 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy