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Secretin (swine)
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Catalog No. T81182Cas No. 17034-35-4
Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it is stimulated by fatty acids and promotes pancreatic secretion of water and bicarbonate. Secretin has diverse effects on organ systems and is utilized in research on the digestive system, central nervous system, and energy metabolism [1][2].
Secretin (swine)
😃Good
Catalog No. T81182Cas No. 17034-35-4
Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it is stimulated by fatty acids and promotes pancreatic secretion of water and bicarbonate. Secretin has diverse effects on organ systems and is utilized in research on the digestive system, central nervous system, and energy metabolism [1][2].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it is stimulated by fatty acids and promotes pancreatic secretion of water and bicarbonate. Secretin has diverse effects on organ systems and is utilized in research on the digestive system, central nervous system, and energy metabolism [1][2]. |
| In vitro | Secretin (swine) at concentrations of 10−7 M and 10−6 M, administered over periods ranging from 24 hours to 72 hours and up to 7 days, enhances biliary growth through engagement with secretin receptors (SR). Additionally, SR knockout diminishes biliary proliferation by attenuating cAMP-dependent signaling pathways [2]. |
| In vivo | Secretin (swine) administered at 2.5 nM/kg body weight per day via osmotic minipumps for one week induces biliary cell proliferation in mice by modulating the levels of microRNA 125b and microRNA let7a [2]. |
| Molecular Weight | 3055.41 |
| Formula | C130H220N44O41 |
| Cas No. | 17034-35-4 |
| Smiles | [C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](C(C)C)C(N)=O)=O)CC(C)C)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)C)=O)CO)=O)CC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)CO)=O)CC(C)C)=O)CCC(O)=O)=O)CO)=O)[C@@H](C)O)=O)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)N)=O)CO)=O)CC(O)=O)=O)=O)[C@@H](C)O)=O |
| Sequence | His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 |
| Sequence Short | HSDGTFTSELSRLRDSARLQRLLQGLV |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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