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(192)
Cytoskeletal Signaling Filter
Cytoskeletal Signaling MetabolismATP Citrate Lyase
(11)
Acetyl-CoA Carboxylase
(13)
Acyltransferase
(40)
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AhR
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(16)
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(8)
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(14)
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(364)
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(68)
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(210)
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(72)
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(104)
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(28)
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(22)
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(17)
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HSP
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.
- TamoxifenT690610540-29-1Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
- $39
SizeQTY
Cited - ElesclomolT6170488832-69-5Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.
- $34
SizeQTY Cited - Palmitic acidT290857-10-3Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms. Palmitic acid has antitumor activity.
- $48
SizeQTY Cited - TriptolideT217938748-32-2Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.
- $37
SizeQTY Cited - CC-99677T393211887069-10-4CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM).
- $123
SizeQTY - TanespimycinT629075747-14-7Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
- $38
SizeQTY
Cited - LuminespibT1989747412-49-3Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β (IC50=7.8 21 nM). Luminespib has antitumor activity and is used in studies of head and neck tumors, among others.
- $52
SizeQTY Cited - VER-155008T70101134156-31-2VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
- $39
SizeQTY Cited - Eupalinolide AT5826877822-40-7Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.
- $66
SizeQTY - OnalespibT6284912999-49-6Onalespib (AT13387) is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.
- $41
SizeQTY Cited - DN401T271932135749-60-7In houseDN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.
- $195
SizeQTY - IPI-493T3218864202-81-9In houseIPI-493 (17-amino17demethoxy) is a novel HSP90 inhibitor with antitumor activity.
- $293
SizeQTY - Arimoclomol maleateT13554289893-26-1Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.
- $39
SizeQTY - HA15T68551609402-14-3HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
- $34
SizeQTY Cited - GeduninT218832753-30-2Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.
- $248
SizeQTY - JG-98T53501456551-16-8JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4 0.7 μM).
- $102
SizeQTY - DihydroberberineT8189483-15-8Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interaction with hERG.
- $41
SizeQTY - Shepherdin 79-87 acetateT12896LShepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.
- $148
SizeQTY - Col003T10860328565-16-8Col003 is a selective and potent inhibitor of Hsp47, competitively binding to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It is useful for researching fibrosis.
- $39
SizeQTY Cited - HSF1AT41251196723-93-9HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis (HSF1).
- $50
SizeQTY - KRIBB11T3652342639-96-7KRIBB11 is an inhibitor of Heat Shock Factor (HSF) [inhibitor].
- $47
SizeQTY - 3-PhenyltoxoflavinT3612332502-63-93-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.
- $58
SizeQTY - GeldanamycinT634330562-34-6Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR) HSP association.
- $39
SizeQTY Cited - HSP27 inhibitor J2T72652133499-85-9HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.
- $79
SizeQTY - 2',4'-DIHYDROXYCHALCONET88291776-30-32',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects
- $50
SizeQTY - RocaglamideTQ013184573-16-0Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.
- $299
SizeQTY - PU-H71 HClT6960L2095432-24-7PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.
- $195
SizeQTY - VER49009T2268940289-57-6VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
- $55
SizeQTY - XL888T62481149705-71-4XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. Through this action, specific clie
- $43
SizeQTY - PaeoniflorinT223023180-57-6Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.
- $41
SizeQTY - NPX800T98041693734-80-3NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.
- $97
SizeQTY - AMP-PCP disodiumT13547L7414-56-4AMP-PCP disodium, an ATP analogue, binds to the N-terminal domain of Hsp90 with a Kd value of 3.8 μM, facilitating the formation of an active Hsp90 homodimer.
- $64
SizeQTY - TRC051384T3527867164-40-7TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated molecular chaperone and anti-inflammatory activity, and enhances Hsp72 expression in neurons and glial cells.
- $31
SizeQTY - NVP-HSP990T6118934343-74-5NVP-HSP990 (HSP990) is an effective and specific HSP90α β inhibitor (IC50: 0.6 0.8 nM).
- $41
SizeQTY - VER-49009T3454558640-51-0VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
- $38
SizeQTY - TeprenoneT50086809-52-5Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
- $46
SizeQTY - Pifithrin-μT621064984-31-2Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
- $39
SizeQTY - NovobiocinT20510303-81-1Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections.
- $35
SizeQTY - GanetespibT2309888216-25-9Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90), exhibiting potential antineoplastic activity.
- $61
SizeQTY Cited - CCT018159T21872171009-07-7CCT018159 is a 3,4-diarylpyrazole resorcinol, an ATP-competitive HSP90ATPase inhibitor that inhibits human Hsp90β and yeast Hsp90 with IC50s of 3.2 and 6.6 μM, respectively.CCT018159 inhibits key endothelial and tumor cell functions associated with invasion and angiogenesis. CCT018159 caused cellular inhibition associated with G1 phase block and induced apoptosis.
- $31
SizeQTY - ApoptozoleT32931054543-47-3Apoptozole (Apoptosis Activator VII) inhibits the ATPase domain of Hsc70 and Hsp70, inducing apoptosis.
- $30
SizeQTY - PimitespibT169941260533-36-5Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α HSP90β inhibitor with inhibition constants (Kis) of 34.7 nM and 21.3 nM, respectively.
- $33
SizeQTY - FalcarinolTN236021852-80-2Falcarinol (Panaxynol) is an Hsp90 inhibitor and CB1 receptor antagonist that inhibits the action of amphetamine on TNF-α-stimulated keratinocytes.
- $440
SizeQTY - HSP70-IN-1T34871268273-90-0HSP70-IN-1 is a heat shock protein (HSP) inhibitor that suppresses the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
- $97
SizeQTY - DTHIBT8858897326-30-6DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
- $30
SizeQTY - KW-2478T6558819812-04-9KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
- $51
SizeQTY Cited - PF04929113T6341908115-27-5PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF04929113 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.
- $33
SizeQTY - EthoxyquinT075691-53-2Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
- $29
SizeQTY - RifabutinT150172559-06-9Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.
- $42
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