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Apramycin sulfate

😃Good

Catalog No. T1084Cas No. 65710-07-8

Alias Nebramycin II, Ai3-29795

Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic.

Apramycin sulfate

😃Good

Purity: 99.96%

Catalog No. T1084Alias Nebramycin II, Ai3-29795Cas No. 65710-07-8

Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$32	In Stock	In Stock
500 mg	$47	In Stock	In Stock
1 g	$64	In Stock	In Stock
5 g	$148	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic.
In vitro	Compared to untreated chicks, 225 mg/L Apramycin completely inhibited mortality and significantly reduced the excretion of Salmonella.
In vivo	At 1/4 MIC, apramycin reduces the growth rate of the test strains in the culture medium and induces a post-antibiotic effect lasting up to 5 hours. It inhibits A. pleuropneumoniae FMV 87-682 with an MIC50 of 8 mg/l. Apramycin significantly decreases the hemolytic activity of A. pleuropneumoniae and affects capsule production in this isolate and in a P. multocida isolate (type A). Misreading induced by apramycin, involving the incorporation of leucine, isoleucine, and serine, was detected, albeit limited to a narrow scope, in an E. coli cell-free system programmed with poly(U).
Synonyms	Nebramycin II, Ai3-29795

Chemical Properties

Molecular Weight	637.66
Formula	C₂₁H₄₃N₅O₁₅S
Cas No.	65710-07-8
Smiles	OS(O)(=O)=O.[H][C@]12C[C@@H](N)[C@@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)O[C@]1([H])[C@H](O)[C@H](NC)[C@@H](O[C@H]1O[C@H](CO)[C@@H](N)[C@H](O)[C@H]1O)O2
Relative Density.	1.56 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mM, Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.5682 mL	7.8412 mL	15.6823 mL	78.4117 mL
5 mM	0.3136 mL	1.5682 mL	3.1365 mL	15.6823 mL
10 mM	0.1568 mL	0.7841 mL	1.5682 mL	7.8412 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc