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CHPG hydrochloride

Name: CHPG hydrochloride
Brand: TargetMol
SKU: T10809L
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10809L

Alias CHPG hydrochloride(170846-74-9 Free base)

CHPG hydrochloride is a selective agonist of mGluR5.

CHPG hydrochloride

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Purity: 99.57%

Catalog No. T10809LAlias CHPG hydrochloride(170846-74-9 Free base)

CHPG hydrochloride is a selective agonist of mGluR5.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$177	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$403	In Stock	In Stock
100 mg	$536	In Stock	In Stock
200 mg	$728	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$103	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CHPG hydrochloride is a selective agonist of mGluR5.
In vitro	After SO2 derivatives treatment, CHPG hydrochloride (10-500 µM) increases the cell viability and reduces the release of LDH. CHPG hydrochloride (0.5 mM) protects BV2 cells against SO2-induced apoptosis and increases the TSG-6 expression through the TSG-6/NF-κB pathway[1].
In vivo	In adult Sprague-Dawley male rats, injection of CHPG hydrochloride (250 nM) reduces significantly cerebral lesion volume by activation of the ERK and Akt signaling pathways[2].
Synonyms	CHPG hydrochloride(170846-74-9 Free base)

Chemical Properties

Molecular Weight	238.07
Formula	C₈H₉Cl₂NO₃
Smiles	O=C(C(C1=CC(O)=CC=C1Cl)N)O.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (126.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2004 mL	21.0022 mL	42.0045 mL	210.0223 mL
5 mM	0.8401 mL	4.2004 mL	8.4009 mL	42.0045 mL
10 mM	0.4200 mL	2.1002 mL	4.2004 mL	21.0022 mL
20 mM	0.2100 mL	1.0501 mL	2.1002 mL	10.5011 mL
50 mM	0.0840 mL	0.4200 mL	0.8401 mL	4.2004 mL
100 mM	0.0420 mL	0.2100 mL	0.4200 mL	2.1002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc