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Asenapine hydrochloride

Name: Asenapine hydrochloride
Brand: TargetMol
SKU: T22589
Rating: 4.5 (1 reviews)

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Catalog No. T22589Cas No. 1261398-77-9

Alias Org 5222 hydrochloride

Asenapine hydrochloride (Org 5222 hydrochloride) is a 5-hydroxytryptamine receptor, adrenergic receptor, dopamine receptor and histamine receptor antagonist with antipsychotic effects used in neurological disorders such as schizophrenia and bipolar disorder.

Asenapine hydrochloride

😃Good

Catalog No. T22589Alias Org 5222 hydrochlorideCas No. 1261398-77-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$69	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Green

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COA

Product Introduction

Bioactivity

Description	Asenapine hydrochloride (Org 5222 hydrochloride) is a 5-hydroxytryptamine receptor, adrenergic receptor, dopamine receptor and histamine receptor antagonist with antipsychotic effects used in neurological disorders such as schizophrenia and bipolar disorder.
Targets&IC50	D4 receptor:1.1 nM (Ki), D2 receptor:1.3 nM (Ki), sPLA2:2.5 nM (Ki), D3 receptor:0.42 nM (Ki), 5-HT2C receptor:0.03 nM (Ki), 5-HT7 receptor:0.13 nM (Ki), 5-HT2A receptor:0.06 nM (Ki)
In vitro	Asenapine hydrochloride acts as an antagonist of 5-HT2A receptors and D2 receptors, commonly used in research related to neurological disorders[2].
Synonyms	Org 5222 hydrochloride

Chemical Properties

Molecular Weight	322.23
Formula	C₁₇H₁₇Cl₂NO
Cas No.	1261398-77-9
Smiles	Cl.[H][C@]12CN(C)C[C@]1([H])c1cc(Cl)ccc1Oc1ccccc21
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1 mg/mL (3.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1034 mL	15.5169 mL	31.0337 mL	155.1687 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc