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Anti-SIGIRR Antibody (2L247) (Synonyms: TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domai...)

Name: Anti-SIGIRR Antibody (2L247)
Brand: TargetMol
SKU: TMAY-02262
Rating: 4.5 (1 reviews)

Catalog No. TMAY-02262 Copy Product Info

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Anti-SIGIRR Antibody (2L247) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (2L247) can be used in ELISA.

Anti-SIGIRR Antibody (2L247)

Copy Product Info

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Catalog No. TMAY-02262

Synonyms TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Anti-SIGIRR Antibody (2L247) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (2L247) can be used in ELISA.

Anti-SIGIRR Antibody
(2L247)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$270	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-SIGIRR Antibody (2L247) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (2L247) can be used in ELISA.
Synonyms	TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Ig Type	Rabbit IgG
Clone	2L247
Reactivity	Human
Specificity	Human SIGIRR No cross-reactivity in ELISA with Mouse SIGIRR Human IL1R1 Human IL1R2 Human IL1R3 Human IL1R7 Human IL1R8 Human IL1R9 Human IL18R1
Application	ELISA
Recommended Dose	ELISA: 1:5000-1:10000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human SIGIRR / TIR8 (rh SIGIRR / TIR8; TMPY-01894; Q6IA17-1; Met1-His118).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human SIGIRR / TIR8 protein (TMPY-01894)
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

TIR-8TIR 8

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