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Anti-SIGIRR Antibody (2L247)
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Catalog No. TMAY-02262
Alias TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Anti-SIGIRR Antibody (2L247) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (2L247) can be used in ELISA.
Anti-SIGIRR Antibody (2L247)
Anti-SIGIRR Antibody (2L247)
😃Good
Catalog No. TMAY-02262Alias TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Anti-SIGIRR Antibody (2L247) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (2L247) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μL | $270 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-SIGIRR Antibody (2L247) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (2L247) can be used in ELISA. |
| Synonyms | TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Ig Type | Rabbit IgG |
| Clone | 2L247 |
| Reactivity | Human |
| Specificity | Human SIGIRR No cross-reactivity in ELISA with Mouse SIGIRR Human IL1R1 Human IL1R2 Human IL1R3 Human IL1R7 Human IL1R8 Human IL1R9 Human IL18R1 |
| Application | |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human SIGIRR / TIR8 (rh SIGIRR / TIR8; TMPY-01894; Q6IA17-1; Met1-His118). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human SIGIRR / TIR8 protein (TMPY-01894) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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